2. Gene
  3. Traf2 - TNF receptor-associated factor 2 Gene

Traf2 - TNF receptor-associated factor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 22030 | 基因类型: protein coding

关于 Traf2

功能概要

Enables CD40 receptor binding activity. Involved in several processes, including interleukin-17-mediated signaling pathway; positive regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to nitric oxide; programmed necrotic cell death; and regulation of JNK cascade. Located in several cellular components, including cytoplasmic side of plasma membrane; membrane raft; and vesicle membrane. Part of CD40 receptor complex and IRE1-TRAF2-ASK1 complex. Is expressed in several structures, including genitourinary system; lower jaw tooth; and mandibular process. Orthologous to human TRAF2 (TNF Receptor associated factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Traf2 基因产物(2)

mRNA Protein Name
NM_001290413.1 NP_001277342.1 TNF receptor-associated factor 2 isoform a
NM_009422.3 NP_033448.2 TNF receptor-associated factor 2 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CD40 receptor binding IPI
IPI: 通过物理相互作用推断
20614026 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9418902 MGI
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
18281285 MGI
enables signaling adaptor activity IDA
IDA: 通过直接分析推断
8710854 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to nitric oxide IMP
IMP: 通过突变表型推断
18007661 MGI
involved in interleukin-17-mediated signaling pathway IDA
IDA: 通过直接分析推断
21822258 MGI
involved in interleukin-17-mediated signaling pathway IMP
IMP: 通过突变表型推断
21822258 MGI
involved in mRNA stabilization IMP
IMP: 通过突变表型推断
21822258 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
15121867 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
8710854 MGI
involved in positive regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: 通过直接分析推断
11374864 MGI
acts upstream of or within programmed necrotic cell death IMP
IMP: 通过突变表型推断
18007661 MGI
acts upstream of or within protein catabolic process IMP
IMP: 通过突变表型推断
12958312 MGI
involved in protein-containing complex assembly IDA
IDA: 通过直接分析推断
20614026 MGI
acts upstream of or within regulation of JNK cascade IDA
IDA: 通过直接分析推断
12958312 MGI
acts upstream of or within regulation of immunoglobulin production IMP
IMP: 通过突变表型推断
12958312 MGI
acts upstream of or within signal transduction IDA
IDA: 通过直接分析推断
12958312 MGI
involved in signal transduction involved in regulation of gene expression IDA
IDA: 通过直接分析推断
21822258 MGI
involved in signal transduction involved in regulation of gene expression IMP
IMP: 通过突变表型推断
21822258 MGI
involved in tumor necrosis factor-mediated signaling pathway IDA
IDA: 通过直接分析推断
8710854 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CD40 receptor complex IDA
IDA: 通过直接分析推断
20614026 MGI
part of IRE1-TRAF2-ASK1 complex IDA
IDA: 通过直接分析推断
12050113 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
11821416 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
20614026 MGI
located in cytosol IDA
IDA: 通过直接分析推断
18007661 MGI
located in membrane raft IDA
IDA: 通过直接分析推断
18007661 MGI
located in vesicle membrane IDA
IDA: 通过直接分析推断
18952128 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

TNF receptor-associated factor 2

E3 ubiquitin-protein ligase TRAF2

RING-type E3 ubiquitin transferase TRAF2

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-19696B Tauroursodeoxycholate dihydrate 99.96% 是
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-16591 Birinapant 99.70% Phase 2
Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100830 NCB-0846 Inhibitor 99.61% 否
HY-138779 ICCB-19 hydrochloride 99.25% 否
HY-134050 Apostatin-1 99.84% 否
HY-124745 KY-05009 99.88% 否
HY-124762 TNIK-IN-1 Inhibitor 98.86% 否
HY-145293 TNIK-IN-3 Inhibitor 99.79% 否
HY-117469 Triptohypol C 96.56% 否
HY-156502 TINK-IN-1 Inhibitor 98.02% 否
HY-156818 TNIK-IN-7 Inhibitor 99.90% 否
HY-100830A NCB-0970 Control 98.78% 否
HY-156817 TNIK-IN-6 Inhibitor 96.92% 否
HY-122805 PF-794 Inhibitor 99.19% 否
HY-145292 TNIK-IN-2 Inhibitor 99.68% 否
HY-RS14197 TANK Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS14968 TRAF2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174514 Human TNFRSF4 mRNA / 否
HY-RS16859 Traf2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23300 Traf2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Traf2 NCBI NCBI:7186
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