1. Vitamin D Related/Nuclear Receptor Autophagy
  2. Nuclear Hormone Receptor 4A/NR4A p62
  3. Triptohypol C

Triptohypol C,Tripterin (HY-13067) 的衍生物,是一种有效的靶向 Nur77 的抗炎剂,Kd 为 0.87 μM。Triptohypol C 通过促进 Nur77 与 TRAF2 和 p62/SQSTM1 的相互作用抑制炎症反应。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Triptohypol C Chemical Structure

Triptohypol C Chemical Structure

CAS No. : 193957-88-9

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
1 mg ¥1636
In-stock
5 mg ¥3600
In-stock
10 mg ¥5800
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].

IC50 & Target

Nur77/NR4A1

 

体外研究
(In Vitro)

Triptohypol C (compound 3a) (2 μM; 1 h) strongly antagonize the effect of TNFα on inducing IκBα degradation, and inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].
Triptohypol C (2 μM; 10 h) cause 3.12% apoptosis in HepG2 cells, which is less toxic than Tripterin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Lysates from HepG2 cells (incubated with 20 ng/mL TNFα for 30 min)
Concentration: 2 μM
Incubation Time: 1 h
Result: Strongly antagonized the effect of TNFα on inducing IκBα degradation

Immunofluorescence[1]

Cell Line: HepG2 cells (transfected with Myc-Nur77 and Flag-TRAF2 or Flag-p62)
Concentration: 2 μM
Incubation Time: 1 h
Result: Promoted the interactions between Nur77 and TRAF2 and p62/SQSTM1.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 2 μM
Incubation Time: 10 h
Result: Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).
体内研究
(In Vivo)

Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zebrafish[1]
Dosage: 0.5 μM, 1 μM and 1.25 μM
Administration: 72 h
Result: Had less effect than Tripterin on the death rate and malformation of zebrafish either at a concentration of 1.25 μM for 24 h or at a concentration of 0.5 μM for 72 h.
分子量

452.63

Formula

C29H40O4

CAS 号
性状

固体

颜色

Light yellow to yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 95.44%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Triptohypol C
目录号:
HY-117469
需求量: