2. Gene
  3. Ttk - Ttk protein kinase Gene

Ttk - Ttk protein kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PYT; esk; Esk1; Mps1

基因 ID: 22137 | 基因类型: protein coding

关于 Ttk

功能概要

Enables identical protein binding activity; kinetochore binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in mitotic spindle assembly checkpoint signaling. Acts upstream of or within several processes, including meiotic spindle assembly checkpoint signaling; protein localization to organelle; and protein phosphorylation. Located in kinetochore. Is expressed in brain; lung; metanephros; and ureteric tip. Orthologous to human TTK (TTK protein kinase). [provided by Alliance of Genome Resources, Apr 2022]

Ttk 基因产物(3)

mRNA Protein Name
NM_001110265.2 NP_001103735.1 dual specificity protein kinase TTK isoform 2
NM_001284272.2 NP_001271201.1 dual specificity protein kinase TTK isoform 3
NM_009445.3 NP_033471.2 dual specificity protein kinase TTK isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21558374 MGI
enables kinetochore binding IMP
IMP: 通过突变表型推断
25197064 MGI
enables protein serine/threonine/tyrosine kinase activity IDA
IDA: 通过直接分析推断
1375325 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within female meiosis chromosome segregation IMP
IMP: 通过突变表型推断
21558374 MGI
acts upstream of or within meiotic prometaphase I IMP
IMP: 通过突变表型推断
21558374 MGI
acts upstream of or within meiotic spindle assembly checkpoint signaling IMP
IMP: 通过突变表型推断
21558374 MGI
involved in mitotic spindle assembly checkpoint signaling IMP
IMP: 通过突变表型推断
25197064 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
1375325 MGI
acts upstream of or within peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
1375325 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
1375325 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: 通过直接分析推断
1375325 MGI
acts upstream of or within protein localization to chromosome IMP
IMP: 通过突变表型推断
21558374 MGI
acts upstream of or within protein localization to kinetochore IMP
IMP: 通过突变表型推断
21558374 MGI
acts upstream of or within protein localization to meiotic spindle midzone IMP
IMP: 通过突变表型推断
21558374 MGI
acts upstream of or within spindle assembly checkpoint signaling IMP
IMP: 通过突变表型推断
32284991 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in kinetochore IDA
IDA: 通过直接分析推断
21558374 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

dual specificity protein kinase TTK

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-101340A Luvixasertib hydrochloride Inhibitor 99.13% Phase 2
HY-143904 PROTAC TTK degrader-1 Antagonist 98.01% Phase 2
HY-101340 Luvixasertib Inhibitor 99.77% Phase 1
Pre-clinical Phase
生物活性分子 (21)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-14710 AZ3146 Inhibitor 99.42% 否
HY-116673 TTK21 Activator 99.39% 否
HY-108709 CC-671 Inhibitor 99.06% 否
HY-100024 NTRC 0066-0 Inhibitor 99.01% 否
HY-19544 JAK3-IN-1 Inhibitor 99.31% 否
HY-144308 RMS-07 Inhibitor / 否
HY-132884 TTK inhibitor 3 Inhibitor / 否
HY-110347 Mps1-IN-1 dihydrochloride Inhibitor / 否
HY-123675 CFI-400936 Inhibitor / 否
HY-143905 PROTAC TTK degrader-2 Antagonist / 否
HY-160419 Mps1-IN-8 Inhibitor / 否
HY-162156 TTK inhibitor 4 Inhibitor / 否
HY-164955 TTK/PLK1-IN-1 Inhibitor / 否
HY-168540 PROTAC MPS1 degrader 1 Degrader / 否
HY-168542 TTK ligand 2 / 否
HY-168543 PROTAC MPS1 degrader 2 Degrader / 否
HY-168545 TTK ligand 3 / 否
HY-RS15226 TTK Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16792 Ttk Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21071 Ttbk2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23232 Ttk Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ttk NCBI NCBI:7272
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