2. Gene
  3. Zap70 - zeta-chain (TCR) associated protein kinase Gene

Zap70 - zeta-chain (TCR) associated protein kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Srk; mur; mrtle; ZAP-70

基因 ID: 22637 | 基因类型: protein coding

关于 Zap70

功能概要

This gene encodes a member of the protein tyrosine kinase family. The encoded protein is essential for development of T lymphocytes and thymocytes, and functions in the initial step of T lymphocyte receptor-mediated signal transduction. A mutation in this gene causes chronic autoimmune arthritis, similar to rheumatoid arthritis in humans. Mice lacking this gene are deficient in alpha-beta T lymphocytes in the thymus. In humans, mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T lymphocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Zap70 基因产物(4)

mRNA Protein Name
NM_001289612.1 NP_001276541.1 tyrosine-protein kinase ZAP-70 isoform TZK
NM_001289765.1 NP_001276694.1 tyrosine-protein kinase ZAP-70 isoform a
NM_001289766.1 NP_001276695.1 tyrosine-protein kinase ZAP-70 isoform b
NM_009539.3 NP_033565.2 tyrosine-protein kinase ZAP-70 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
8798454 MGI
enables phosphotyrosine residue binding IPI
IPI: 通过物理相互作用推断
8196616 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8551236 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
14738763 MGI
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
8798454 MGI
enables protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
9208839 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of T cell differentiation IMP
IMP: 通过突变表型推断
9208839 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
9208839 MGI
acts upstream of alpha-beta T cell differentiation IGI
IGI: 通过遗传相互作用推断
9275205 MGI
acts upstream of alpha-beta T cell differentiation IMP
IMP: 通过突变表型推断
7630421 MGI
acts upstream of or within beta selection IGI
IGI: 通过遗传相互作用推断
9275205 MGI
acts upstream of calcium-mediated signaling IMP
IMP: 通过突变表型推断
7630421 MGI
acts upstream of or within intracellular signal transduction IMP
IMP: 通过突变表型推断
7630421 MGI
acts upstream of or within negative thymic T cell selection IMP
IMP: 通过突变表型推断
7630421 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
8798454 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
9208839 MGI
acts upstream of or within positive regulation of T cell differentiation IMP
IMP: 通过突变表型推断
9208839 MGI
acts upstream of or within positive regulation of alpha-beta T cell differentiation IGI
IGI: 通过遗传相互作用推断
9275205 MGI
acts upstream of or within positive regulation of alpha-beta T cell differentiation IMP
IMP: 通过突变表型推断
7630421 MGI
acts upstream of or within positive regulation of alpha-beta T cell proliferation IGI
IGI: 通过遗传相互作用推断
9275205 MGI
acts upstream of or within positive regulation of calcium-mediated signaling IMP
IMP: 通过突变表型推断
7630421 MGI
acts upstream of or within positive thymic T cell selection IMP
IMP: 通过突变表型推断
7630421 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: 通过直接分析推断
8798454 MGI
acts upstream of or within protein autophosphorylation IMP
IMP: 通过突变表型推断
9208839 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
9169414 MGI
acts upstream of or within thymic T cell selection IMP
IMP: 通过突变表型推断
9208839 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
23793062 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
17028588 MGI
located in cytosol IDA
IDA: 通过直接分析推断
9182527 MGI
located in immunological synapse IDA
IDA: 通过直接分析推断
17028588 MGI
located in membrane IDA
IDA: 通过直接分析推断
15599401 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
17028588 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein kinase ZAP-70

70 kDa zeta-chain associated protein

syk-related tyrosine kinase

Zap70 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Zap70 P43404 Cd247 Mus musculus P24161
Anti Bait CoIP
24034254
种属内
Zap70 P43404 Cd247 Mus musculus P24161
Affinity Chrom
24584089
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-15322 PRT062607 Inhibitor 99.38% Phase 2
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136179 ZAP-180013 Inhibitor 99.88% 否
HY-155978A RDN2150 TFA Inhibitor 99.80% 否
HY-155978 RDN2150 Inhibitor / 否
HY-112319 MK-8457 Inhibitor / 否
HY-RS15951 ZAP70 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17310 Zap70 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23765 Zap70 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99129 Anti-Mouse CD8a Antibody (53-6.7) Inhibitor 95.00% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Zap70 NCBI NCBI:7535
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