2. Gene
  3. Plcg2 - phospholipase C, gamma 2 Gene

Plcg2 - phospholipase C, gamma 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Plcg-2; PLCgamma2; PLC-gamma-2

基因 ID: 234779 | 基因类型: protein coding

关于 Plcg2

功能概要

Enables phosphatidylinositol Phospholipase C activity and phosphorylation-dependent protein binding activity. Involved in several processes, including immune response-regulating signaling pathway; positive regulation of cytokine production; and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including activation of store-operated Calcium Channel activity; follicular B cell differentiation; and regulation of calcium-mediated signaling. Located in cytosol. Is expressed in several structures, including alimentary system; bone; cardiovascular system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (Phospholipase C gamma 2). [provided by Alliance of Genome Resources, Apr 2022]

Plcg2 基因产物(1)

mRNA Protein Name
NM_172285.2 NP_758489.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol phospholipase C activity EXP
EXP: 通过实验结果推断
8615781 MGI
enables phosphorylation-dependent protein binding IPI
IPI: 通过物理相互作用推断
10744659 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8395016 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B cell differentiation IMP
IMP: 通过突变表型推断
10925250 MGI
involved in B cell receptor signaling pathway IMP
IMP: 通过突变表型推断
10925250 MGI
acts upstream of or within T cell receptor signaling pathway IDA
IDA: 通过直接分析推断
15728238 MGI
acts upstream of or within activation of store-operated calcium channel activity IMP
IMP: 通过突变表型推断
15611229 MGI
involved in antifungal innate immune response IMP
IMP: 通过突变表型推断
22041900 MGI
involved in cell activation IMP
IMP: 通过突变表型推断
19136564 MGI
involved in cellular response to lectin IMP
IMP: 通过突变表型推断
19136564 MGI
acts upstream of or within follicular B cell differentiation IMP
IMP: 通过突变表型推断
12928432 MGI
acts upstream of or within inositol trisphosphate biosynthetic process IDA
IDA: 通过直接分析推断
9013981 MGI
involved in intracellular signal transduction IMP
IMP: 通过突变表型推断
19136564 MGI
involved in macrophage activation involved in immune response IMP
IMP: 通过突变表型推断
22041900 MGI
acts upstream of or within negative regulation of programmed cell death IMP
IMP: 通过突变表型推断
12928432 MGI
acts upstream of or within positive regulation of DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
19136564 MGI
involved in positive regulation of I-kappaB phosphorylation IMP
IMP: 通过突变表型推断
22041900 MGI
involved in positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
19136564 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
19136564 MGI
acts upstream of or within positive regulation of calcium-mediated signaling IMP
IMP: 通过突变表型推断
19136564 MGI
involved in positive regulation of dendritic cell cytokine production IMP
IMP: 通过突变表型推断
19136564 MGI
involved in positive regulation of interleukin-10 production IMP
IMP: 通过突变表型推断
19136564 MGI
involved in positive regulation of interleukin-12 production IMP
IMP: 通过突变表型推断
22041900 MGI
involved in positive regulation of interleukin-2 production IMP
IMP: 通过突变表型推断
19136564 MGI
involved in positive regulation of interleukin-23 production IMP
IMP: 通过突变表型推断
19136564 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
19136564 MGI
acts upstream of positive regulation of macrophage cytokine production IMP
IMP: 通过突变表型推断
22041900 MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
22041900 MGI
acts upstream of positive regulation of reactive oxygen species biosynthetic process IMP
IMP: 通过突变表型推断
22041900 MGI
involved in positive regulation of receptor internalization IMP
IMP: 通过突变表型推断
22078883 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
19136564 MGI
involved in positive regulation of type I interferon production IMP
IMP: 通过突变表型推断
22078883 MGI
acts upstream of programmed cell death IMP
IMP: 通过突变表型推断
12928432 MGI
acts upstream of or within regulation of calcineurin-NFAT signaling cascade IMP
IMP: 通过突变表型推断
19136564 MGI
involved in regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
19136564 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
12928432 MGI
involved in release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
10925250 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: 通过直接分析推断
9013981 MGI
involved in response to yeast IMP
IMP: 通过突变表型推断
22041900 MGI
involved in stimulatory C-type lectin receptor signaling pathway IMP
IMP: 通过突变表型推断
19136564 MGI
involved in toll-like receptor signaling pathway IMP
IMP: 通过突变表型推断
19136564 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IMP
IMP: 通过突变表型推断
10925250 MGI
located in membrane raft IDA
IDA: 通过直接分析推断
23478294 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

phosphoinositide phospholipase C-gamma-2

Plcg2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Plcg2 Q8CIH5 Fhl2 Mus musculus O70433
Y2H
15102471
种属内
Plcg2 Q8CIH5 Inpp5d Mus musculus Q9ES52
Y2H
15102471
种属内
Plcg2 Q8CIH5 Pdcd6ip Mus musculus Q9WU78
Y2H
15102471
种属内
Plcg2 Q8CIH5 Fn1 Mus musculus P11276
Y2H
15102471
种属内
Plcg2 Q8CIH5 Flna Mus musculus Q8BTM8
Y2H
15102471
种属内
Plcg2 Q8CIH5 Trim27 Mus musculus Q62158
Y2H
15102471
种属内
Plcg2 Q8CIH5 Zbtb7b Mus musculus Q64321
Y2H
15102471
种属内
Plcg2 Q8CIH5 Lyn Mus musculus P25911
Pull Down
8395016
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10661 PLCG2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19471 Plcg2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25964 Plcg2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Plcg2 NCBI NCBI:5336
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