2. Gene
  3. Parp3 - poly (ADP-ribose) polymerase family, member 3 Gene

Parp3 - poly (ADP-ribose) polymerase family, member 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：聚 (ADP-核糖) 聚合酶家族，成员 3

种属: Mus musculus

同用名: ARTD3; Adprt3; PARP-3; ADPRT-3; Adprtl3; pADPRT-3; A930002C11Rik

基因 ID: 235587 | 基因类型: protein coding

关于 Parp3

Chromosome 9: 106,347,521-106,354,148 reverse strand.GRCm39:CM001002.3

This gene has 9 transcripts (splice variants), 198 orthologues and 2 paralogues. Broad expression in subcutaneous fat pad adult (RPKM 25.), bladder adult (RPKM 19.6) and 18 other tissues.

功能概要

预测该基因编码的蛋白可启动 NAD DNA ADP-核糖基转移酶活性； NAD+ ADP-核糖基转移酶活性；和蛋白质 ADP-核糖基酶活性。参与同种型转换的负调节。作用于双链断裂修复的上游或内部。位于双链断裂位点。与人类 PARP3（聚（ADP-核糖）聚合酶家族成员 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable NAD DNA ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; and protein ADP-ribosylase activity. Involved in negative regulation of isotype switching. Acts upstream of or within double-strand break repair. Located in site of double-strand break. Orthologous to human PARP3 (poly(ADP-ribose) polymerase family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Parp3 基因产物(2)

mRNA Protein Name
NM_001311150.1 NP_001298079.1 protein mono-ADP-ribosyltransferase PARP3 isoform 1
NM_145619.3 NP_663594.2 protein mono-ADP-ribosyltransferase PARP3 isoform 2
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within double-strand break repair IGI
IGI: 通过遗传相互作用推断
21270334 MGI
involved in negative regulation of isotype switching IMP
IMP: 通过突变表型推断
26000965 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in site of double-strand break IDA
IDA: 通过直接分析推断
21270334 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Parp3 蛋白结构

WGR

WGR: cl01581 (55 - 153)

parp_like

parp_like: cd01437 (175 - 526)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 528 a.a.
蛋白主名 其他名称

protein mono-ADP-ribosyltransferase PARP3

A DP-ribosyltransferase (NAD+

poly (ADP-ribose polymerase)-like 3

ADP-ribosyltransferase (NAD+, poly (ADP-ribose polymerase)-like 3

ADP-ribosyltransferase diphtheria toxin-like 3

DNA ADP-ribosyltransferase PARP3

NAD(+) ADP-ribosyltransferase 3

NAD+ ADP-ribosyltransferase 3

Poly[ADP-ribose] synthetase-3

poly [ADP-ribose] polymerase 3

poly[ADP-ribose] synthase 3

相关产品

Approval
生物活性分子 (11)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10619 Niraparib Inhibitor 99.96% 是
HY-10617A Rucaparib Inhibitor 99.97% 否
HY-10617 Rucaparib phosphate Inhibitor 99.76% 是
HY-10619A Niraparib hydrochloride Inhibitor 99.41% 是
HY-10619B Niraparib tosylate Inhibitor 99.99% 是
HY-102003 Rucaparib (monocamsylate) Inhibitor 99.82% 是
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% 是
HY-10617C Rucaparib tartrate Inhibitor / 否
HY-102003A Rucaparib camsylate Inhibitor / 否
HY-10617D Rucaparib acetate Inhibitor / 否
HY-10617B Rucaparib hydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-13536 AZD-2461 Inhibitor 99.79% Phase 1
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148566 OUL232 Inhibitor 99.86% 否
HY-150207 RBN-3143 Inhibitor 99.24% 否
HY-100225 ME0328 Inhibitor 99.64% 否
HY-148754 PARP10-IN-3 Inhibitor 98.89% 否
HY-155993 YCH1899 Inhibitor 99.39% 否
HY-148753 PARP10-IN-2 Inhibitor 98.02% 否
HY-W294889 OUL245 Inhibitor / 否
HY-100847 AZ0108 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Parp3 NCBI NCBI:10039
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z