2. Gene
  3. KIF4A - kinesin family member 4A Gene

KIF4A - kinesin family member 4A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：驱动蛋白家族成员 4A

种属: Homo sapiens

同用名: KIF4; KIF4G1; MRX100; XLID100

基因 ID: 24137 | 基因类型: protein coding

关于 KIF4A

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:70,290,104-70,420,886 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues, 41 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 4.3), lymph node (RPKM 2.9) and 14 other tissues.

功能概要

该基因编码驱动蛋白相关蛋白驱动蛋白 4 亚家族的成员。编码的蛋白质是一种 ATP 依赖性微管驱动蛋白，参与膜细胞器的细胞内运输。这种蛋白质还与浓缩染色体臂相关，并可能参与维持有丝分裂期间的染色体完整性。这种蛋白质也可能参与胞质分裂前的中央纺锤体的组织。在 X 染色体上发现了该基因的假基因。[RefSeq 提供，2010 年 3 月]

This gene encodes a member of the Kinesin 4 subfamily of Kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during Mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]

KIF4A 基因产物(1)

mRNA Protein Name
NM_012310.5 NP_036442.3 chromosome-associated kinesin KIF4A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16431929 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitotic cytokinesis IMP
IMP: 通过突变表型推断
15843429 GOA
involved in mitotic spindle midzone assembly IMP
IMP: 通过突变表型推断
15843429 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in midbody IDA
IDA: 通过直接分析推断
15166316 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KIF4A 蛋白结构

Kinesin

Kinesin: Kinesin motor domain (15 - 336)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1232 a.a.
蛋白主名 其他名称

chromosome-associated kinesin KIF4A

chromokinesin-A

KIF4A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
KIF4A O95239 PHF14 Homo sapiens O94880-1
Anti Bait CoIP
28160558
种属内
KIF4A O95239 PHF14 Homo sapiens O94880
Anti Bait CoIP
28160558
种属内
KIF4A O95239 PHF14 Homo sapiens O94880
Confocal
28160558
种属间: 跨种属相互作用 种属内: 同种属相互作用

KIF4A 抗体

目录号 产品名 应用 反应物种
HY-P82908 KIF4A Antibody (YA2653) WB, FC Human, Mouse

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, X-Linked 100

XLID100

Mental Retardation, X-Linked 100

Mrx100

Mental Retardation, X-Linked, Type 100
Multicystic Dysplastic Kidney

Multicystic Renal Dysplasia

Multicystic Kidney Dysplasia

Mcdk

Multiple Congenital Cysts Of Kidney

Developmental Multicystic Kidney
Hydrocephalus, Congenital, 1

Hydrocephaly

Ventriculomegaly

Hydrocephalus, Nonsyndromic, Autosomal Recessive 1

HYC1

Congenital Non-Communicating Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive 1, Formerly

Congenital Obstructive Hydrocephalus

Hydrocephalus, Non-Syndromic, Autosomal Recessive 1

Hydrocephalus
Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive

Hydrocephalus, X-Linked

Hydrocephalus Adverse Event

Hydrocephaly Nos
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
Charcot-Marie-Tooth Disease, Axonal, Type 2dd

CMT2DD

Charcot-Marie-Tooth Neuropathy, Type 2dd

Charcot-Marie-Tooth Disease Type 2dd

Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2

Atp1a1-Related Cmt2

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd

Charcot-Marie-Tooth Disease 2dd
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07288 KIF4A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26550 Kif4a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta KIF4A VGNC VGNC:103830
Rattus norvegicus KIF4A RGD RGD:620526
Mus musculus KIF4A MGD MGI:108389
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