2. Gene
  3. PHF14 - PHD finger protein 14 Gene

PHF14 - PHD finger protein 14 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PHD 指蛋白 14

种属: Homo sapiens

基因 ID: 9678 | 基因类型: protein coding

关于 PHF14

Cytogenetic location: 7p21.3 Genomic coordinates (GRCh38): 7:10,973,872-11,169,618 (from NCBI)

This gene has 16 transcripts (splice variants), 210 orthologues and 8 paralogues. Ubiquitous expression in brain (RPKM 4.6), endometrium (RPKM 2.7) and 25 other tissues.

功能概要

预测启用组蛋白结合活性。预计参与组蛋白 H3-K14 乙酰化和 RNA 聚合酶 II 的转录调控。预计在几个过程的上游或内部起作用，包括肺泡发育；参与肺发育的间充质细胞增殖的负调节；血小板衍生生长因子受体-α 信号通路的负调控。预测位于核内。预计是 MOZ/MORF 组蛋白乙酰转移酶复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable histone binding activity. Predicted to be involved in histone H3-K14 acetylation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including lung alveolus development; negative regulation of mesenchymal cell proliferation involved in lung development; and negative regulation of platelet-derived growth factor receptor-alpha signaling pathway. Predicted to be located in nucleus. Predicted to be part of MOZ/MORF Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

PHF14 基因产物(2)

mRNA Protein Name
NM_001007157.2 NP_001007158.1 PHD finger protein 14 isoform 1
NM_014660.4 NP_055475.2 PHD finger protein 14 isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone binding IDA
IDA: 通过直接分析推断
23688586 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28160558 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
23688586 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
23688586 GOA
located in nucleus IDA
IDA: 通过直接分析推断
23688586 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PHF14 蛋白结构

PHD

PHD: PHD-finger (321 - 379)

zf-HC5HC2H_2

zf-HC5HC2H_2: PHD-zinc-finger like domain (384 - 498)

PHD

PHD: PHD-finger (728 - 778)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 888 a.a.
蛋白主名 其他名称

PHD finger protein 14

PHF14 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PHF14 O94880 KIF4A Homo sapiens O95239
Anti Bait CoIP
28160558
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ceroid Lipofuscinosis, Neuronal, 9

Neuronal Ceroid Lipofuscinosis 9

CLN9

Cln 9

Cln9 Disease
Dandy-Walker Syndrome

Dandy-Walker Malformation

DWS

Atresia Of Foramina Of Magendie And Luschka

Dandy-Walker Complex

Dandy-Walker Cyst

Dandy-Walker Deformity

Dandy Walker Cyst

Dw Complex

Dandy-Walker Syndrome Or Malformation

Dandy-Walker Variant

Mega Cisterna Magna

Dwm

Hydrocephalus, Internal, Dandy-Walker Type

Hydrocephalus, Noncommunicating, Dandy-Walker Type

Luschka-Magendie Foramina Atresia

Isolated Dandy-Walker Malformation

Mega-Cisterna Magna

Dandy Walker Variant

Atresia Of Foramen Of Luschka

Atresia Of Foramen Of Magendie

Congenital Blockage Of Foramen Magendie
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10418 PHF14 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PHF14 RGD RGD:1563764
Mus musculus PHF14 MGD MGI:1923539
Canis familiaris PHF14 VGNC VGNC:44483
Macaca mulatta PHF14 VGNC VGNC:75847
Felis catus PHF14 VGNC VGNC:64139
Bos taurus PHF14 VGNC VGNC:32816
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