Casr - calcium-sensing receptor Gene

中文名称：钙敏感受体

种属: Rattus norvegicus

同用名: PCaR1; RaKCaR

基因 ID: 24247 | 基因类型: protein coding

关于 Casr

Primary_assembly 11: 64,235,251-64,304,811 forward strand.mRatBN7.2:CM026984.1

This gene has 2 transcripts (splice variants), 203 orthologues, 98 paralogues and is associated with 39 phenotypes. Restricted expression toward (RPKM 159.2).

功能概要

该基因编码的蛋白可启动整合素结合活动；蛋白激酶结合活性；和跨膜转运蛋白结合活性。参与多个过程，包括G蛋白偶联受体信号通路；血管直径维持；和细胞化学稳态。位于几种细胞成分中，包括顶端质膜；基底外侧质膜；和神经细胞体。用于研究心肌病。动脉粥样硬化的生物标志物；心肌梗塞;和肺动脉高压。该基因的人类直系同源物与多种疾病有关，包括常染色体显性低钙血症（多种）；高钙血症（多发性）；甲状旁腺功能亢进症（多发性）；特发性全身性癫痫 8；和肾结石（多发）。与人类 CASR（钙敏感受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Integrin binding activity; protein kinase binding activity; and transmembrane transporter binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; blood vessel diameter maintenance; and cellular chemical homeostasis. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Used to study cardiomyopathy. Biomarker of atherosclerosis; myocardial infarction; and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Orthologous to human CaSR (calcium sensing receptor). [provided by Alliance of Genome Resources, Apr 2022]

Casr 基因产物(2)

mRNA	Protein	Name
NM_016996.2	NP_058692.1	extracellular calcium-sensing receptor precursor
NM_001309638.1	NP_001296567.1	extracellular calcium-sensing receptor precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables integrin binding	IPI IPI: 通过物理相互作用推断	21969374	RGD
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	20383739	RGD
enables transmembrane transporter binding	IPI IPI: 通过物理相互作用推断	21084311	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in JNK cascade	IMP IMP: 通过突变表型推断	15084499	RGD
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	22192592	RGD
involved in bile acid secretion	IDA IDA: 通过直接分析推断	11071898	RGD
involved in branching morphogenesis of an epithelial tube	IMP IMP: 通过突变表型推断	20117086	RGD
involved in cellular response to glucose stimulus	IEP IEP: 通过表达模式推断	21146545	RGD
involved in cellular response to hepatocyte growth factor stimulus	IEP IEP: 通过表达模式推断	21088907	RGD
involved in cellular response to hypoxia	IEP IEP: 通过表达模式推断	21073657	RGD
involved in cellular response to low-density lipoprotein particle stimulus	IEP IEP: 通过表达模式推断	22083546	RGD
involved in cellular response to peptide	IEP IEP: 通过表达模式推断	22678567	RGD
involved in cellular response to vitamin D	IEP IEP: 通过表达模式推断	21940515	RGD
involved in chloride transmembrane transport	IDA IDA: 通过直接分析推断	7816802	RGD
involved in detection of calcium ion	IDA IDA: 通过直接分析推断	7816802	RGD
involved in fat pad development	IEP IEP: 通过表达模式推断	21940515	RGD
involved in intracellular calcium ion homeostasis	IDA IDA: 通过直接分析推断	12065312	RGD
involved in ossification	IMP IMP: 通过突变表型推断	15084499	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	22192592	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	22192592	RGD
involved in positive regulation of calcium ion import	IMP IMP: 通过突变表型推断	22098336	RGD
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	12700162	RGD
involved in positive regulation of insulin secretion	IMP IMP: 通过突变表型推断	22566534	RGD
involved in positive regulation of positive chemotaxis	IMP IMP: 通过突变表型推断	20117086	RGD
involved in positive regulation of vasoconstriction	IMP IMP: 通过突变表型推断	22098336	RGD
involved in response to calcium ion	IEP IEP: 通过表达模式推断	20431039	RGD
involved in response to fibroblast growth factor	IEP IEP: 通过表达模式推断	20431039	RGD
involved in response to ischemia	IEP IEP: 通过表达模式推断	21488219	RGD
involved in response to metal ion	IEP IEP: 通过表达模式推断	22312704	RGD
involved in response to organic cyclic compound	IEP IEP: 通过表达模式推断	19092814	RGD
involved in vasodilation	IMP IMP: 通过突变表型推断	15084499	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical plasma membrane	IDA IDA: 通过直接分析推断	22517767	RGD
located in axon	IDA IDA: 通过直接分析推断	22517767	RGD
located in axon terminus	IDA IDA: 通过直接分析推断	7724534	RGD
located in basolateral plasma membrane	IDA IDA: 通过直接分析推断	22517767	RGD
located in cell surface	IDA IDA: 通过直接分析推断	21969374	RGD
located in neuronal cell body	IDA IDA: 通过直接分析推断	22517767	RGD
is active in presynaptic membrane	IDA IDA: 通过直接分析推断	20052292	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Casr 蛋白结构

PBP1_CaSR

NCD3G

7tmC_CaSR

0
200
400
600
800
1000
1079 a.a.

蛋白主名

其他名称

extracellular calcium-sensing receptor

Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)

parathyroid Cell calcium-sensing receptor

相关产品

Approval

生物活性分子 (8)

目录号	产品名	作用方式	纯度	是否罕见病
HY-70037	Cinacalcet	Agonist	99.93%	是
HY-70037A	Cinacalcet hydrochloride	Agonist	99.98%	是
HY-P1955A	Etelcalcetide hydrochloride	Activator	99.31%	否
HY-17613	Evocalcet	Activator	98.39%	否
HY-17397	Strontium Ranelate	Activator	99.99%	否
HY-109106A	Upacicalcet sodium	Agonist	99.91%	否
HY-P1955	Etelcalcetide	Activator	/	否
HY-109106	Upacicalcet	Agonist	/	否

Clinical Phase

生物活性分子 (2)

目录号	产品名	作用方式	纯度	Phase
HY-10007	NPS-2143	Antagonist	99.94%	Phase 2
HY-10167A	Tecalcet Hydrochloride	Modulator	99.66%	Phase 2

Pre-clinical Phase

生物活性分子 (41)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-139201A	Poly-D-lysine hydrobromide (MW 70000-150000)	Agonist	99.86%	否
HY-103314	Gadolinium chloride	Agonist	99.99%	否
HY-139201	Poly-D-lysine hydrobromide (MW 30000-70000)	Agonist	/	否
HY-112171	γ-L-Glutamyl-L-alanine	Modulator	≥98.0%	否
HY-10171	NPS-2143 hydrochloride	Antagonist	99.98%	否
HY-12557	γ-Glutamylvaline	Activator	99.73%	否
HY-103320A	Calhex 231 hydrochloride	Inhibitor	99.81%	否
HY-11095	NPS 2390	Inhibitor	99.90%	否
HY-N0546	Ligustroflavone	Antagonist	99.90%	否
HY-139201B	Poly-D-lysine hydrobromide (MW 84000)	Agonist	/	否
HY-117851	AC-265347	Agonist	99.97%	否
HY-50713	Calcium-Sensing receptor antagonist I	Antagonist	98.95%	否
HY-122819	Calindol hydrochloride	Agonist	99.88%	否
HY-103320B	(1R,2R)-Calhex 231 hydrochloride	Control	99.07%	否
HY-P4376A	Gamma-Glu-Abu TFA	Agonist	96.10%	否
HY-14401	Encaleret	Antagonist	99.88%	否
HY-121584	Lycoperodine-1	Agonist	99.82%	否
HY-107773	GSK3004774	Agonist	98.11%	否
HY-W843885	H-Glu-Thr-OH	Activator	98.63%	否
HY-15105	SB-423562	Antagonist	99.66%	否
HY-15104	Ronacaleret hydrochloride	Antagonist	99.81%	否
HY-70037AS	Cinacalcet-d3 hydrochloride	Agonist	97.63%	否
HY-103320	Calhex 231	Antagonist	/	否
HY-177303	AXT-914	Inhibitor	/	否
HY-109106B	(Rac)-Upacicalcet		≥95.0%	否
HY-10167	Tecalcet	Modulator	/	否
HY-153258	CaSR antagonist-1	Antagonist	/	否
HY-W777503	Calindol hydrochloride-13C,D2		/	否
HY-14752	Ronacaleret	Antagonist	/	否
HY-139201E	Poly-D-lysine hydrobromide (MW 150000-300000)		/	否
HY-139201C	Poly-D-lysine hydrobromide (MW 1000-5000)		/	否
HY-139201H	Poly-D-lysine hydrobromide (MW ≥300000)		/	否
HY-15106	SB-423557	Antagonist	/	否
HY-P4376	Gamma-Glu-Abu	Agonist	/	否
HY-139201D	Poly-D-lysine hydrobromide (MW 4000-15000)		/	否
HY-70037S	Cinacalcet-D3	Agonist	/	否
HY-17613S	Evocalcet-d4	Activator	/	否
HY-W653978	Cinacalcet-d4 hydrochloride	Agonist	/	否
HY-171446	TAK-075	Antagonist	/	否
HY-161113	Z8554052021	Activator	/	否
HY-112171R	γ-L-Glutamyl-L-alanine (Standard)	Modulator	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Casr	NCBI	NCBI:846

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