2. GPCR/G Protein
  3. CaSR
  4. Ronacaleret hydrochloride

Ronacaleret hydrochloride  (Synonyms: SB 751689A)

目录号: HY-15104
产品使用指南

摩尔计算器

Ronacaleret hydrochloride (SB 751689A) 是一种口服活性、高效、选择性的钙感应受体 (CaSR) 拮抗剂，能刺激甲状旁腺释放内源性甲状旁腺激素。Ronacaleret hydrochloride (SB 751689A) 用于研究绝经后骨质疏松症.

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Ronacaleret hydrochloride Chemical Structure

Ronacaleret hydrochloride Chemical Structure

CAS No. : 702686-96-2

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Other Forms of Ronacaleret hydrochloride:

Ronacaleret hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ronacaleret hydrochloride (SB 751689A) is an orally active, potent, and selective calcium-sensing receptor (CaSR) antagonist that stimulates endogenous parathyroid hormone release from the parathyroid glands. Ronacaleret hydrochloride (SB 751689A) is used for the study of postmenopausal osteoporosis[1].

体外研究
(In Vitro)

Ronacaleret抑制OATP1B1 (IC50 = 11 μM) 和OATP2B1 (IC50 = 12 μM) 的体外活性，而不抑制BCRP[3].
Ronacaleret被显示出抑制OATP1B1和OATP1B3介导的探针底物雌二醇-葡萄糖醛酸酯的摄取，相对效力较低 (IC50 值分别为11和60 μM)[3].
Ronacaleret在pH 7.4和pH 6.0下抑制OATP2B1介导的瑞舒伐他汀运输，IC50值分别为16和12 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ronacaleret hydrochloride 相关抗体:
体内研究
(In Vivo)

Ronacaleret (SB 751689，3 mg/kg/天) 在5/6肾切除大鼠中保持了klotho表达和肾功能，同时降低了血清磷和白蛋白尿[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 7-week-old Wistar rats[2].
Dosage: 3 mg/kg/day (dissolved in 10% β-cyclodextrin solution).
Administration: Administered by an osmotic pump that was implanted subcutaneously.
Result: Increased renal expression of klotho in a dose-dependent manner.
Decreased serum phosphate and FGF23 with the increased fractional excretion of phosphate without changes in serum calcium.
Appeared to similarly protect podocytes.
Reduced FGF23 and because FGF23 enhanced klotho expression.
分子量

483.98

Formula

C25H32ClF2NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ronacaleret hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Ronacaleret702686-96-2SB 751689ACaSRCalcium-sensing receptorparathyroid hormonepostmenopausal osteoporosisOATP2B1OATP1B1Inhibitorinhibitorinhibit

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