2. Gene
  3. Gls - glutaminase Gene

Gls - glutaminase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：谷氨酰胺酶

种属: Rattus norvegicus

同用名: Glut; RATGLUT

基因 ID: 24398 | 基因类型: protein coding

关于 Gls

Primary_assembly 9: 49,344,781-49,416,900 forward strand.mRatBN7.2:CM026982.1

This gene has 3 transcripts (splice variants), 305 orthologues, 1 paralogue and is associated with 9 phenotypes. Biased expression in Kidney (RPKM 45.8), Brain (RPKM 295.5) and 9 other tissues.

功能概要

预测该基因编码的蛋白可启动谷氨酰胺酶活性和相同的蛋白质结合活性。预计参与谷氨酸稳态；谷氨酰胺家族氨基酸代谢过程；和蛋白质同源四聚化。预计在化学突触传递的上游或内部起作用；通过神经系统过程调节呼吸气体交换；和哺乳行为。位于线粒体中。该基因的人类直向同源基因与发育和癫痫性脑病 71 相关。与人类 GLS（谷氨酰胺酶）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Glutaminase activity and identical protein binding activity. Predicted to be involved in glutamate homeostasis; glutamine family amino acid metabolic process; and protein homotetramerization. Predicted to act upstream of or within chemical synaptic transmission; regulation of respiratory gaseous exchange by nervous system process; and suckling behavior. Located in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (Glutaminase). [provided by Alliance of Genome Resources, Apr 2022]

Gls 基因产物(2)

mRNA Protein Name
NM_001109968.3 NP_001103438.2 glutaminase kidney isoform, mitochondrial isoform b
NM_012569.4 NP_036701.3 glutaminase kidney isoform, mitochondrial isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16899818 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Gls 蛋白结构

EF-hand_14

EF-hand_14: pfam17959 (142 - 225)

Glutaminase

Glutaminase: pfam04960 (247 - 531)

Ank_2

Ank_2: pfam12796 (560 - 652)

ANK

ANK: sd00045 (560 - 586)

ANK

ANK: sd00045 (588 - 620)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
蛋白主名 其他名称

glutaminase kidney isoform, mitochondrial

K-glutaminase

L-glutamine amidohydrolase

kidney-type glutaminase

相关产品

Clinical Phase
生物活性分子 (7)
目录号 产品名 作用方式
纯度 Phase
HY-12248 Telaglenastat 99.82% Phase 2
HY-108917 Morphothiadin Inhibitor 99.79% Phase 2
HY-128357 Ibezapolstat Inhibitor 98.0% Phase 2
HY-P2760 Glutaminase / Phase 2
HY-108917A Morphothiadin mesylate Inhibitor / Phase 2
HY-103671 IPN60090 Inhibitor 99.47% Phase 1
HY-103671A IPN60090 dihydrochloride Inhibitor 99.68% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99109 Zimberelimab Inhibitor 99.90% Phase 3
Pre-clinical Phase
生物活性分子 (20)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-79583 Glutaminase-IN-3 Inhibitor 99.88% 否
HY-150109A Purinostat Inhibitor / 否
HY-136704 GLS1 Inhibitor-1 Inhibitor 98.5% 否
HY-144666 GLS-1-IN-1 Inhibitor 99.64% 否
HY-RS05500 GLS Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-151434 GLS1 Inhibitor-6 / 否
HY-12248A Telaglenastat hydrochloride / 否
HY-128357A Ibezapolstat hydrochloride Inhibitor / 否
HY-146616 GLS1 Inhibitor-3 Inhibitor / 否
HY-146617 GLS1 Inhibitor-4 / 否
HY-146658 Glutaminase-IN-4 Inhibitor / 否
HY-148241 A-446 Inhibitor / 否
HY-152207 LWG-301 / 否
HY-155138 GLS1 Inhibitor-7 Inhibitor / 否
HY-174211 JNK-IN-23 Inhibitor / 否
HY-RS05501 Gls Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS05502 Gls Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS05503 GLS2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17808 Gls2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24276 Gls2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gls NCBI NCBI:2744
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