1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Glutaminase

Glutaminase

Glutaminase is an amidohydrolase enzyme that generates glutamate from glutamine. Glutamate production by mitochondrial glutaminase is a key process for body homeostasis, and a crucial carbon donor for amino acid and lipid synthesis in tumor cells.

Glutaminase has tissue-specific isoenzymes. Three mammalian glutaminases have been identified: the liver-type [LGA or GLS2], the kidney-type [KGA] and Glutaminase C [GAC] a splice variant of KGA (both usually referred to as GLS1). GLS1 is a therapeutic target for cancer. GLS1 catalyzes the hydrolysis of glutamine to glutamate, which is used in the citric acid cycle (TCA) of cancer cells undergoing an aberrant glycolytic flux as a non-glucose-derived source for anaplerosis. GAC plays an essential role in the transformation of NIH 3T3 fibroblasts by Rho GTPases, as well as in the proliferative and invasive activities of various cancer cells.

Glutaminase 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-12683
    BPTES Inhibitor 98.07%
    BPTES是选择性的谷氨酰胺酶变构抑制剂,IC50 为0.16 μM。
  • HY-108357
    6-Diazo-5-oxo-L-nor-Leucine Antagonist >99.0%
    L-6-Diazo-5-oxonorleucine (L-6-Diazo-5-oxonorleucine) 是一种谷氨酰胺拮抗剂,其Ki 值为 6 μM。L-6-Diazo-5-oxonorleucine 具有镇痛、抗菌、抗病毒和抗癌作用。L-6-Diazo-5-oxonorleucine 在体外表现出遗传毒性。L-6-Diazo-5-oxonorleucine 能降低肿瘤细胞的自我更新能力和转移能力 。
  • HY-12682
    Glutaminase C-IN-1 Inhibitor 99.61%
    Glutaminase C-IN-1 (Compound 968) 是 Glutaminase C 变构抑制剂。
  • HY-12337
    GK921 Inhibitor 99.92%
    GK921是转谷氨酰胺酶2 (TGase2) 抑制剂,对人类重组TGase2的IC50值为7.71 μM。
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