2. Gene
  3. Nedd4 - NEDD4 E3 ubiquitin protein ligase Gene

Nedd4 - NEDD4 E3 ubiquitin protein ligase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Nedd4a

基因 ID: 25489 | 基因类型: protein coding

关于 Nedd4

功能概要

Enables protein C-terminus binding activity and ubiquitin-protein transferase activity. Involved in several processes, including regulation of postsynaptic neurotransmitter receptor internalization; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; and response to denervation involved in regulation of muscle adaptation. Located in membrane raft and microvillus. Is active in glutamatergic synapse. Biomarker of muscular atrophy. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Nedd4 基因产物(1)

mRNA Protein Name
NM_012986.1 NP_037118.1 E3 ubiquitin-protein ligase NEDD4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
8665844 RGD
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
20159449 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in immune response IEP
IEP: 通过表达模式推断
11248052 RGD
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
20159449 RGD
involved in regulation of dendrite morphogenesis IDA
IDA: 通过直接分析推断
20159449 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: 通过直接分析推断
21148011 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IEP
IEP: 通过表达模式推断
21148011 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: 通过突变表型推断
21148011 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IDA
IDA: 通过直接分析推断
21148011 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IEP
IEP: 通过表达模式推断
21148011 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IMP
IMP: 通过突变表型推断
21148011 RGD
involved in regulation protein catabolic process at postsynapse IDA
IDA: 通过直接分析推断
21148011 RGD
involved in regulation protein catabolic process at postsynapse IEP
IEP: 通过表达模式推断
21148011 RGD
involved in regulation protein catabolic process at postsynapse IMP
IMP: 通过突变表型推断
21148011 RGD
involved in response to denervation involved in regulation of muscle adaptation IEP
IEP: 通过表达模式推断
19125695 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
21148011 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
21148011 RGD
located in microvillus IDA
IDA: 通过直接分析推断
9227416 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

E3 ubiquitin-protein ligase NEDD4

HECT-type E3 ubiquitin transferase NEDD4

neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

neural precursor cell expressed, developmentally down-regulated gene 4

neural precursor cell expressed, developmenta

相关产品

Pre-clinical Phase
生物活性分子 (16)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110204 Heclin Inhibitor 98.21% 否
HY-134417 NSC2805 Inhibitor 99.42% 否
HY-162809 XMU-MP-9 99.12% 否
HY-N10159 1-Benzyl-I3C 99.68% 否
HY-110174 NAB2 Degrader 99.69% 否
HY-153178 HECT E3-IN-1 Inhibitor 99.43% 否
HY-122046 Amb123203 98.87% 否
HY-124791 MMRi6 99.70% 否
HY-174375 NEDD4-IN-1 / 否
HY-174415 ZSH-2117 / 否
HY-RS09179 NEDD4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS09180 NEDD4L Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17116 Nedd4l Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17232 Nedd4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23561 Nedd4l Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23685 Nedd4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nedd4 NCBI NCBI:4734
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