TNFRSF21 - TNF receptor superfamily member 21 Gene

中文名称：TNF 受体超家族成员 21

种属: Homo sapiens

同用名: DR6; CD358; BM-018

关于 TNFRSF21

功能概要

该基因编码肿瘤坏死因子受体超家族的一个成员。编码的蛋白质激活核因子 kappa-B 和丝裂原活化蛋白激酶 8 (也称为 c-Jun N-末端激酶 1) ，并诱导细胞凋亡。通过其死亡域，编码的受体与肿瘤坏死因子受体 1 型相关死亡域 (TRADD) 蛋白相互作用，已知后者可介导肿瘤坏死因子受体的信号转导。小鼠基因敲除研究表明，该基因在 T 辅助细胞激活中发挥作用，并可能参与炎症和免疫调节。[RefSeq 提供，2013 年 7 月]

This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell Apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]