2. Gene
  3. Grn - granulin precursor Gene

Grn - granulin precursor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: PEPI; PGRN

基因 ID: 29143 | 基因类型: protein coding

关于 Grn

功能概要

Predicted to enable chaperone binding activity. Involved in several processes, including chondrocyte proliferation; positive regulation of dendritic spine development; and response to estradiol. Predicted to be located in several cellular components, including late endosome; lysosomal membrane; and trans-Golgi network. Predicted to be active in extracellular region. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor). [provided by Alliance of Genome Resources, Apr 2022]

Grn 基因产物(2)

mRNA Protein Name
NM_001145842.1 NP_001139314.1 progranulin isoform b precursor
NM_017113.2 NP_058809.2 progranulin isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17307734 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chondrocyte proliferation IMP
IMP: 通过突变表型推断
17307734 RGD
involved in male mating behavior IMP
IMP: 通过突变表型推断
10764901 RGD
involved in neural precursor cell proliferation IMP
IMP: 通过突变表型推断
17179653 RGD
involved in positive regulation of dendritic spine development IMP
IMP: 通过突变表型推断
21813674 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
21813674 RGD
involved in response to estradiol IDA
IDA: 通过直接分析推断
17179653 RGD
involved in synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
21813674 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
24046442 RGD
is active in synapse IDA
IDA: 通过直接分析推断
24046442 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

progranulin

acrogranin

epithelin

granulins

proepithelin

prostate cancer cell-derived growth factor

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12854 Imetelstat Inhibitor 99.43% 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P4073 ANG1005 98.83% Phase 3
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99688 Latozinemab Inhibitor 96.03% Phase 3
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-115733 Cathepsin L-IN-2 Inhibitor 98.02% 否
HY-RS17678 Grn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS05843 GRN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-124393 GRN-529 Modulator / 否
HY-RS24139 Grn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grn NCBI NCBI:2896
Mus musculus Grn NCBI NCBI:14824
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