Erbb3 - erb-b2 receptor tyrosine kinase 3 Gene

中文名称：erb-b2 受体酪氨酸激酶3

种属: Rattus norvegicus

同用名: nuc-ErbB3

关于 Erbb3

功能概要

该基因编码的蛋白可启动神经调节蛋白结合活性和神经调节蛋白受体活性。参与多个过程，包括动物器官发育；细胞对胰岛素刺激的反应；积极调节葡萄糖输入。位于细胞核和突触后膜。慢性阻塞性肺病和正中神经病变的生物标志物。该基因的人类直系同源物与致死性先天性挛缩综合征 2 相关；肺腺癌；肺非小细胞癌；和神经元肠发育不良 A 型。与人 ERBB3（erb-b2 受体酪氨酸激酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables neuregulin binding activity and neuregulin receptor activity. Involved in several processes, including animal organ development; cellular response to Insulin stimulus; and positive regulation of glucose import. Located in nucleus and postsynaptic membrane. Biomarker of chronic obstructive pulmonary disease and median neuropathy. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]