2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR MAPK/ERK Pathway
  3. EGFR PI3K Akt p38 MAPK
  4. Lumretuzumab

Lumretuzumab  (Synonyms: 鲁妥珠单抗; Anti-Human ERBB3 Recombinant Antibody)

目录号: HY-P99304 纯度: ≥99.0%
COA 技术支持

Lumretuzumab (Anti-Human ERBB3 Recombinant Antibody) 是一种人源化的抗 HER3 (ERBB3) 单克隆抗体。Lumretuzumab 有效抑制 PI3K/AKT 和 MAPK 等关键致癌信号通路的活性。Lumretuzumab 经过糖基工程化优化，可增强抗体依赖性细胞介导的细胞毒性 (ADCC) 作用。Lumretuzumab 可用于研究 HER3 阳性、HER2 低表达的实体肿瘤，特别是乳腺癌。

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CAS No. : 1448327-63-6

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Lumretuzumab 相关抗体

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lumretuzumab (Anti-Human ERBB3 Recombinant Antibody) is a humanized anti-HER3 (ERBB3) monoclonal antibody. Lumretuzumab effectively inhibits the activity of key oncogenic signaling pathways such as PI3K/AKT and MAPK. Lumretuzumab has been optimized through glycosyl engineering to enhance antibody-dependent cell-mediated cytotoxicity (ADCC). Lumretuzumab can be used to study HER3-positive, HER2-low-expressing solid tumors, especially breast cancer[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target[1]

HER3

 

体外研究
(In Vitro)

Lumretuzumab (10 μM, 1 h) 在 MCF-7 细胞中有效抑制 HRG 刺激后的 HER2、HER3 及 AKT 磷酸化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lumretuzumab 相关抗体:

Western Blot Analysis[2]

Cell Line: MCF-7 cells
Concentration: 10 μM
Incubation Time: 1 h
Result: Effectively inhibited the phosphorylation of HER3 and the downstream AKT signaling pathway.
体内研究
(In Vivo)

Lumretuzumab (10 mg/kg, i.p., 每周一次共 40-70 天) 在 ER+/HER2 低表达的乳腺癌小鼠异种移植模型中单药可诱导肿瘤停滞，联合 Pertuzumab (HY-P9912) 可诱导肿瘤长期消退，且加入 Fulvestrant (HY-13636) 后疗效进一步改善[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ER+/HER2-low/HER3+ human breast cancer xenotransplantation model established in female nu/nu mice[2]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), once a week for 40-70 days
Result: Specifically inhibited the activation of HER3 and blocks the signal transduction induced by HRG.
Induced tumor arrest, achieved significant tumor regression through combination with Pertuzumab, and the efficacy was optimal when combined with Fulvestrant.
Clinical Trial
基因 ID

2065  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

146.92 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

鲁妥珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized HER3 Protein, Human (HEK293, His, HY-P72625) can bind Lumretuzumab. The EC50 for this effect is 3.513 ng/mL.
  • Flow cytometric analysis of 1X106 MCF-7 cells with Lumretuzumab (HY-P99304, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
纯度 & 产品资料

纯度: ≥99.0%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Lumretuzumab 相关分类

  • 摩尔计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lumretuzumab1448327-63-6Anti-Human ERBB3 Recombinant Antibody鲁妥珠单抗EGFRPI3KAktp38 MAPKEpidermal growth factor receptorErbB-1HER1Phosphoinositide 3-kinasePKBProtein kinase BHER3PertuzumabEstrogen receptor(ER)CrosstalkBreast cancerInhibitorinhibitorinhibit

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