2. Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. IGF-1R EGFR
  4. Istiratumab

Istiratumab  (Synonyms: MM 141; MM-005)

目录号: HY-P99672

摩尔计算器

Istiratumab (M-6495) 是靶向 IGF-1R 和 ErbB3 的双特异性单克隆抗体。Istiratumab 通过蛋白酶体途径诱导 IGF-1R 和 ErbB3 受体降解。Istiratumab 可用于癌症研究。

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Istiratumab Chemical Structure

Istiratumab Chemical Structure

CAS No. : 1509928-04-4

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Istiratumab 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Istiratumab (M-6495) is bispecific monoclonal antibody targeting IGF-1R and ErbB3. Istiratumab induces IGF-1R and ErbB3 receptor degradation through the proteasome pathway Istiratumab can be used for research of cancers[1][2][3].

体外研究
(In Vitro)

Istiratumab (500 nM，24 小时) 在人胰腺癌细胞系中抑制 IGF-1 和 HRG 共刺激引起的AKT 激活[2]。
Istiratumab (500 nM，24 小时) 抑制具有激活 KRAS 突变的胰腺癌细胞中 IGF-1 和 HRG 诱导的 AKT 磷酸化[2]。
Istiratumab (500 nM, 24 h) 通过蛋白酶体途径诱导 IGF-1R 和 ErbB3 受体降解[2]。
Istiratumab (1 μM，60 分钟) 阻断卵巢癌细胞系中 PI3K 和 MAPK 信号级联的激活[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Istiratumab 相关抗体:

Western Blot Analysis[2]

Cell Line: AsPC1, BxPC3, Capan2, CFPAC1, etc.
Concentration: 500 nM
Incubation Time: 24 h
Result: Decreased IGF-1R and/or ErbB3 protein levels in pancreatic cancer cell lines.
Clinical Trial
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Istiratumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Istiratumab1509928-04-4MM 141 MM-005MM141MM-141MM005MM 005MM-005IGF-1REGFRInsulin-like growth factor-1 receptorEpidermal growth factor receptorErbB-1HER1OV90cancerpancreatic cancerovarian cancerInhibitorinhibitorinhibit

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