Ptgs2 - prostaglandin-endoperoxide synthase 2 Gene

种属: Rattus norvegicus

同用名: Cox2; COX-2; PGHS-2; PHS II

关于 Ptgs2

功能概要

Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and positive regulation of cytokine production. Acts upstream of or within bone mineralization. Located in cytoplasm. Part of protein-containing complex. Colocalizes with caveola. Used to study several diseases, including Barrett's esophagus; brain disease (multiple); hypertension (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including carcinoma (multiple); glioblastoma (multiple); inflammatory bowel disease (multiple); pleurisy; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); avian influenza; cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2). [provided by Alliance of Genome Resources, Apr 2022]