2. GPCR/G Protein Immunology/Inflammation Apoptosis
  3. Neuropeptide S Receptor Interleukin Related TNF Receptor
  4. NPSR1 antagonist-1

NPSR1 antagonist-1 是一种强效且具有外周限制性的神经肽 S 受体 1 (NPSR1) 拮抗剂。NPSR1 antagonist-1 能够抑制 IL-6、PTGS2、IL-20 和 CXCL8 的表达。NPSR1 antagonist-1 可降低 TNF-α 细胞因子水平。NPSR1 antagonist-1 可用于炎症相关研究，例如腹膜炎。

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NPSR1 antagonist-1

NPSR1 antagonist-1 Chemical Structure

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NPSR1 antagonist-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NPSR1 antagonist-1 is a potent and peripherally restricted neuropeptide S receptor 1 (NPSR1) antagonist. NPSR1 antagonist-1 can inhibit IL-6, PTGS2, IL-20, and CXCL8 expression. NPSR1 antagonist-1 can reduce TNF-α cytokine levels. NPSR1 antagonist-1 can be used for the research of inflammation, such as peritonitis[1].

IC50 & Target[1]

IL-6

 

IL-20

 

TNF-α

 

体外研究
(In Vitro)

NPSR1 antagonist-1 (Compound 6) 对 NPSR1-A 和 NPSR1-B 的 IC50 值分别为 0.35 nM 和 0.15 nM[1]。
NPSR1 antagonist-1 在 HEK293T 细胞中对 Npsr1 的抑制作用的 IC50 值为 2.1 nM[1]。
NPSR1 antagonist-1 (0.001-10000 nM, 30 mins) 可降低表达 NPSR1-A 的成纤维细胞中 IL6、CXCL8、IL20 和 PTGS2 的水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NPSR1 antagonist-1 相关抗体:

RT-PCR[1]

Cell Line: NPSR1-A expressing fibroblasts
Concentration: 0.001, 0.01, 0.1, 1, 10,100, 1000 and 10000 nM
Incubation Time: 30 mins
Result: Reduced IL6, CXCL8, IL20, and PTGS2 levels.
体内研究
(In Vivo)

NPSR1 antagonist-1 (Compound 6) (10 mg/kg，腹腔注射，在酵母聚糖注射前) 可促进酵母聚糖诱导的腹膜炎小鼠模型的炎症消退[1]。
NPSR1 antagonist-1 (40 mg/kg，腹腔注射，在酵母聚糖注射前) 可降低酵母聚糖诱导的腹膜炎小鼠模型的腹膜中 TNF-α 的水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zymosan-induced peritonitis mice models[1]
Dosage: 10 mg/kg
Administration: Intraperitoneally injection, before zymosan injection
Result: Increased the number of F4/80+ resident macrophages in the peritoneum.
分子量

528.68

Formula

C30H42F2N4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NPSR1 antagonist-1 相关分类

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  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NPSR1 antagonist-1Neuropeptide S ReceptorInterleukin RelatedTNF ReceptorNPSRGPR154Vasopressin receptor-related receptor 1VRR1ILTumor Necrosis Factor ReceptorTNFRNPSR1IL-6PTGS2IL-20CXCL8TNF-αPeritonitisHEK293TFibroblastsInhibitorinhibitorinhibit

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