2. Gene
  3. Cyp11a1 - cytochrome P450, family 11, subfamily a, polypeptide 1 Gene

Cyp11a1 - cytochrome P450, family 11, subfamily a, polypeptide 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Cyp11a; Cypxia1; P450scc; P450(scc)

基因 ID: 29680 | 基因类型: protein coding

关于 Cyp11a1

功能概要

Enables Cholesterol binding activity and Cholesterol monooxygenase (side-chain-cleaving) activity. Involved in several processes, including nervous system development; response to vitamin; and steroid biosynthetic process. Located in mitochondrial crista and perikaryon. Biomarker of several diseases, including glucose metabolism disease (multiple); hypertension; nephrosis; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (Cytochrome P450 family 11 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp11a1 基因产物(1)

mRNA Protein Name
NM_017286.3 NP_058982.1 cholesterol side-chain cleavage enzyme, mitochondrial precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in C21-steroid hormone biosynthetic process IDA
IDA: 通过直接分析推断
19665544 RGD
involved in Leydig cell differentiation IEP
IEP: 通过表达模式推断
18502897 RGD
involved in Schwann cell differentiation IEP
IEP: 通过表达模式推断
18373277 RGD
involved in biphenyl metabolic process IEP
IEP: 通过表达模式推断
19071209 RGD
involved in cellular response to antibiotic IEP
IEP: 通过表达模式推断
18655822 RGD
involved in cellular response to cAMP IEP
IEP: 通过表达模式推断
17719163 RGD
involved in cellular response to cadmium ion IEP
IEP: 通过表达模式推断
17719163 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: 通过表达模式推断
17494997 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: 通过表达模式推断
20810564 RGD
involved in cellular response to gonadotropin stimulus IEP
IEP: 通过表达模式推断
9397943 RGD
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
9397943 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
20665543 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: 通过表达模式推断
19416745 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
18511507 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
9397943 RGD
involved in cerebellum development IEP
IEP: 通过表达模式推断
16329132 RGD
involved in dibenzo-p-dioxin metabolic process IEP
IEP: 通过表达模式推断
18637154 RGD
involved in granulosa cell differentiation IEP
IEP: 通过表达模式推断
2176216 RGD
involved in hippocampus development IEP
IEP: 通过表达模式推断
21047951 RGD
involved in male gonad development IEP
IEP: 通过表达模式推断
18772241 RGD
involved in maternal process involved in female pregnancy IEP
IEP: 通过表达模式推断
17726144 RGD
involved in mating behavior IMP
IMP: 通过突变表型推断
16101892 RGD
involved in organic acid metabolic process IEP
IEP: 通过表达模式推断
17400581 RGD
involved in phenol-containing compound metabolic process IEP
IEP: 通过表达模式推断
18191889 RGD
involved in phthalate metabolic process IEP
IEP: 通过表达模式推断
18923996 RGD
involved in response to L-ascorbic acid IEP
IEP: 通过表达模式推断
17280759 RGD
involved in response to alkaloid IEP
IEP: 通过表达模式推断
18772241 RGD
involved in response to amino acid IEP
IEP: 通过表达模式推断
18040670 RGD
involved in response to cAMP IEP
IEP: 通过表达模式推断
2176216 RGD
involved in response to cadmium ion IEP
IEP: 通过表达模式推断
15223132 RGD
involved in response to corticosterone IEP
IEP: 通过表达模式推断
18335507 RGD
involved in response to estrogen IEP
IEP: 通过表达模式推断
12715917 RGD
involved in response to fungicide IEP
IEP: 通过表达模式推断
14967917 RGD
involved in response to gamma radiation IEP
IEP: 通过表达模式推断
18046538 RGD
involved in response to genistein IEP
IEP: 通过表达模式推断
16214947 RGD
involved in response to gonadotropin IEP
IEP: 通过表达模式推断
19929576 RGD
involved in response to hydrogen peroxide IMP
IMP: 通过突变表型推断
14635199 RGD
involved in response to insecticide IEP
IEP: 通过表达模式推断
19892000 RGD
involved in response to ionizing radiation IEP
IEP: 通过表达模式推断
18821396 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
16844298 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
18606229 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
18609294 RGD
involved in response to salt stress IEP
IEP: 通过表达模式推断
7678819 RGD
involved in response to steroid hormone IEP
IEP: 通过表达模式推断
19961867 RGD
involved in response to vitamin E IEP
IEP: 通过表达模式推断
17280759 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
20144211 RGD
involved in steroid biosynthetic process IMP
IMP: 通过突变表型推断
17218406 RGD
involved in testosterone biosynthetic process IEP
IEP: 通过表达模式推断
19883722 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial crista IDA
IDA: 通过直接分析推断
11691658 RGD
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
21075169 RGD
located in mitochondrion IDA
IDA: 通过直接分析推断
2170421 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
16632873 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cholesterol side-chain cleavage enzyme, mitochondrial

cholesterol desmolase

cholesterol side-chain cleavage cytochrome P450

cytochrome P450 11A1

cytochrome P450 11a cholesterol side chain cleavage

cytochrome P450 family 11 subfamily a

cytochrome P450 side-chain cleavage enzyme

cytochrome P450 subfamily

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-16276 Osilodrostat Inhibitor 99.90% 是
HY-16276A Osilodrostat phosphate Inhibitor 98.83% 是
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-156628 Opevesostat Inhibitor 99.79% Phase 3
Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-130705A Tachysterol 3 99.68% 否
HY-156530 CYP11A1-IN-1 Inhibitor 99.64% 否
HY-101217 BI 689648 Inhibitor 99.20% 否
HY-135281 CYP11B2-IN-1 Inhibitor 99.83% 否
HY-151140 CYP11B1-IN-2 Inhibitor / 否
HY-176480 CYP11B2-IN-3 Inhibitor / 否
HY-RS03434 CYP11A1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS03435 CYP11B1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-163751 STING-IN-9 Inhibitor / 否
HY-RS17315 Cyp11b1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17479 Cyp11a1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23770 Cyp11b1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23937 Cyp11a1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cyp11a1 NCBI NCBI:1583
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