2. Gene
  3. Cacna1d - calcium voltage-gated channel subunit alpha1 D Gene

Cacna1d - calcium voltage-gated channel subunit alpha1 D Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 29716 | 基因类型: protein coding

关于 Cacna1d

功能概要

Enables PDZ domain binding activity; ankyrin binding activity; and high voltage-gated Calcium Channel activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of CREB transcription factor activity; and positive regulation of transport. Located in several cellular components, including apical plasma membrane; dendrite membrane; and sarcolemma. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1d 基因产物(1)

mRNA Protein Name
NM_001389225.2 NP_001376154.1 voltage-dependent L-type calcium channel subunit alpha-1D
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IDA
IDA: 通过直接分析推断
17287512 RGD
enables ankyrin binding IPI
IPI: 通过物理相互作用推断
21859974 RGD
enables high voltage-gated calcium channel activity IDA
IDA: 通过直接分析推断
18322004 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
20627102 RGD
enables voltage-gated calcium channel activity IDA
IDA: 通过直接分析推断
11487617 RGD
enables voltage-gated calcium channel activity IMP
IMP: 通过突变表型推断
17050707 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcium ion import IMP
IMP: 通过突变表型推断
16706838 RGD
involved in calcium ion transport IDA
IDA: 通过直接分析推断
21859974 RGD
involved in calcium-mediated signaling IDA
IDA: 通过直接分析推断
7479909 RGD
involved in cellular response to amyloid-beta IEP
IEP: 通过表达模式推断
21822937 RGD
involved in heart development IEP
IEP: 通过表达模式推断
21378599 RGD
involved in memory IEP
IEP: 通过表达模式推断
12591156 RGD
involved in metal ion transport IMP
IMP: 通过突变表型推断
17287512 RGD
involved in optic nerve development IEP
IEP: 通过表达模式推断
22473424 RGD
involved in positive regulation of CREB transcription factor activity IMP
IMP: 通过突变表型推断
16706838 RGD
involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP
IMP: 通过突变表型推断
25675390 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
23229155 RGD
involved in positive regulation of membrane depolarization IDA
IDA: 通过直接分析推断
7760845 RGD
involved in regulation of calcium ion transport IDA
IDA: 通过直接分析推断
21859974 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
19593990 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
14637163 RGD
located in cell surface IDA
IDA: 通过直接分析推断
21822937 RGD
located in dendrite membrane IDA
IDA: 通过直接分析推断
16706838 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
19136044 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
19665524 RGD
located in primary dendrite IDA
IDA: 通过直接分析推断
19136044 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
21378599 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

voltage-dependent L-type calcium channel subunit alpha-1D

CaV1.3alpha1

RBD

brain class D

calcium channel alpha-1 subunit

calcium channel, L type, alpha-1 polypeptide

calcium channel, voltage-dependent, L type, alpha 1D subunit

voltage-dependent calcium channel subunit alpha1D

voltage-gated calcium channel

Cacna1d 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Cacna1d P27732 Gabbr2 Rattus norvegicus O88871
Pull Down
20627102
种属内
Cacna1d P27732 Gabbr2 Rattus norvegicus O88871
IF
20627102
种属内
Cacna1d P27732 Gabbr2 Rattus norvegicus O88871
Anti Bait CoIP
20627102
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01794 CACNA1D Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20625 Cacna1d Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27134 Cacna1d Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cacna1d NCBI NCBI:776
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