Lrrk2 - leucine-rich repeat kinase 2 Gene

中文名称：富含亮氨酸重复激酶 2

种属: Rattus norvegicus

关于 Lrrk2

功能概要

预计该基因编码的蛋白可启动多项功能，包括 GTP 绑定活动；细胞骨架蛋白结合活性；和蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括神经系统发育；大分子代谢过程的正向调控；和小胶质细胞活化的正调节。位于多个细胞成分中，包括轴突；树突;和周核体。用于研究神经退行性疾病。糖尿病神经病变的生物标志物。该基因的人类直系同源物与克罗恩病有关；帕金森病；帕金森病 8；帕金森症；和癌症。与人类 LRRK2（富含亮氨酸重复激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including GTP binding activity; cytoskeletal protein binding activity; and protein serine/threonine kinase activity. Involved in several processes, including nervous system development; positive regulation of macromolecule metabolic process; and positive regulation of microglial cell activation. Located in several cellular components, including axon; dendrite; and perikaryon. Used to study neurodegenerative disease. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and Cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Apr 2022]