Atf6 - activating transcription factor 6 Gene

中文名称：激活转录因子 6

种属: Rattus norvegicus

关于 Atf6

功能概要

该基因编码的蛋白可启动泛素蛋白连接酶结合活性。预计参与多个过程，包括内质网未折叠蛋白反应； ATF6 介导的未折叠蛋白反应的正调控；响应内质网应激，RNA 聚合酶 II 启动子转录的正调控。预测作用于 RNA 聚合酶 II 的自噬正调控和转录正调控的上游或内部。位于细胞质和细胞核中。博尔纳病的生物标志物。该基因的人类直系同源物与全色盲 7 相关。与人类 ATF6（激活转录因子 6）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including endoplasmic reticulum unfolded protein response; positive regulation of ATF6-mediated unfolded protein response; and positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress. Predicted to act upstream of or within positive regulation of Autophagy and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Biomarker of borna disease. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]