2. Peptides
  3. LPPM-8

LPPM-8 是 Med25 的配体，也是 Med25 蛋白-蛋白相互作用 (PPI) 的抑制剂。LPPM-8 通过与其激活剂相互作用域的 H2 面来与 Med25 相互作用，并稳定细胞蛋白质组中的全长蛋白质。LPPM-8 是 H2 结合转录激活剂 (例如 ATF6a) 的正位抑制剂。LPPM-8 可用于研究 Med25 和其 Mediator complex 的复杂生物学。

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Custom Peptide Synthesis

LPPM-8 Chemical Structure

LPPM-8 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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LPPM-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology[1].

体外研究
(In Vitro)

Med25 是 megadalton Mediator complex 的亚化学计量成分，通过蛋白相互作用与两亲性 ETV/PEA3 家族 (细胞迁移、运动)、ATF6a (应激反应) 和 VP16 (病毒感染) 在转录起始过程中桥接介体和转录激活因子[1]。
LPPM-8 (10 和 20 μM) 会抑制 VARIO68 细胞中的 Med25 依赖性基因 (MMP-9)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LPPM-8 相关抗体:
分子量

1012.28

Formula

C50H89N7O14
Sequence

{(2S,3R)-3-Hydroxy-2-methylundecanoyl}-{d-(Glu-Asp-Leu-Leu-Leu-Leu-Val)}
Sequence Shortening

{(2S,3R)-3-Hydroxy-2-methylundecanoyl}-{d-(EDLLLLV)}
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LPPM-8LPPM8LPPM 8OthersInhibitorinhibitorinhibit

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