2. Gene
  3. Abcg2 - ATP binding cassette subfamily G member 2 Gene

Abcg2 - ATP binding cassette subfamily G member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ATP 结合盒亚家族 G 成员 2

种属: Rattus norvegicus

同用名: Bcrp; BCRP1

基因 ID: 312382 | 基因类型: protein coding

关于 Abcg2

Primary_assembly 4: 87,745,319-87,802,409 forward strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 312 orthologues, 9 paralogues and is associated with 38 phenotypes. Biased expression in Kidney (RPKM 256.7), Brain (RPKM 36.1) and 6 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括细胞骨架蛋白结合活性；流出跨膜转运蛋白活性；和外源性跨膜转运蛋白活性。参与多个过程，包括细胞对脂质的反应；参与女性妊娠的胚胎过程；和尿酸盐排泄。位于顶端质膜和细胞核的外侧。糖尿病生物标志物；继发性甲状旁腺功能亢进症;癫痫持续状态；和 2 型糖尿病。该基因的人类直系同源物与痛风有关；血液系统癌症（多发性）；肾细胞癌；和中毒性脑病。与人类 ABCG2 同源（ATP 结合盒亚家族 G 成员 2（初级血型））。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including cytoskeletal protein binding activity; efflux transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including cellular response to lipid; embryonic process involved in female pregnancy; and urate salt excretion. Located in external side of apical plasma membrane and nucleus. Biomarker of diabetes mellitus; secondary hyperparathyroidism; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in gout; hematologic Cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Abcg2 基因产物(1)

mRNA Protein Name
NM_181381.2 NP_852046.1 broad substrate specificity ATP-binding cassette transporter ABCG2

Abcg2 蛋白结构

3a01204

3a01204: cl36780 (45 - 650)

  • 0
  • 200
  • 400
  • 600
  • 657 a.a.
蛋白主名 其他名称

broad substrate specificity ATP-binding cassette transporter ABCG2

ATP binding cassette subfamily G member 2 (Junior blood group)

ATP-binding cassette protein G2

ATP-binding cassette sub-family G member 2

ATP-binding cassette, sub-family G (WHITE), member 2

ATP-binding cassette, subfamily G (WHITE), member 2

breast cancer resistance protein 1 homolog

urate exporter

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10440 Vismodegib 99.97% 是
HY-101561 Avapritinib Inhibitor 99.94% 是
HY-B1153A Glafenine hydrochloride Inhibitor 99.03% 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-109019 Vorolanib Inhibitor 99.88% Phase 3
HY-10527C Telatinib mesylate Inhibitor 99.46% Phase 2
Pre-clinical Phase
生物活性分子 (28)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10010 Ko 143 Inhibitor 99.97% 否
HY-N2143 Fumitremorgin C Inhibitor 99.20% 否
HY-11079 A-803467 Inhibitor 99.09% 否
HY-101453 Ceefourin 1 98.03% 否
HY-18010 PCI 29732 Inhibitor 99.86% 否
HY-100933 MY-5445 Inhibitor 99.86% 否
HY-112505 Efflux inhibitor-1 Inhibitor ≥98.0% 否
HY-144305 KPH2f Inhibitor 98.05% 否
HY-113805 MC70 Inhibitor 99.50% 否
HY-151432 URAT1 inhibitor 3 Inhibitor 98.02% 否
HY-111678 ML230 Inhibitor 99.60% 否
HY-103439 GW583340 dihydrochloride Inhibitor / 否
HY-122416 6,8-Diprenylnaringenin Inhibitor / 否
HY-129301 CCTA-1523 Inhibitor / 否
HY-136450 Triclabendazole sulfoxide Inhibitor 98.78% 否
HY-136450S Triclabendazole sulfoxide-d3 Inhibitor / 否
HY-136450S1 Triclabendazole sulfoxide-13C,d3 Inhibitor / 否
HY-146676 UR-MB108 Inhibitor / 否
HY-155652 ABCG2-IN-1 Inhibitor / 否
HY-155653 ABCG2-IN-2 Inhibitor / 否
HY-156092 Antitumor photosensitizer-4 / 否
HY-P5391 LL-37(17-32) Inhibitor / 否
HY-RS00077 ABCG2 Human Pre-designed siRNA Set A / 否
HY-RS00078 Abcg2 Mouse Pre-designed siRNA Set A / 否
HY-RS00079 Abcg2 Rat Pre-designed siRNA Set A / 否
HY-119724 ABCG2-IN-3 Inhibitor / 否
HY-149469 3,7,2',4'-Tetramethoxy-5-hydroxyflavone Inhibitor / 否
HY-N2651 5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Abcg2 NCBI NCBI:9429
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