2. Gene
  3. ABCB5 - ATP binding cassette subfamily B member 5 Gene

ABCB5 - ATP binding cassette subfamily B member 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ATP 结合盒亚家族 B 成员 5

种属: Homo sapiens

同用名: ABCB5beta; EST422562; ABCB5alpha

基因 ID: 340273 | 基因类型: protein coding

关于 ABCB5

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:20,615,667-20,757,008 (from NCBI)

This gene has 6 transcripts (splice variants), 136 orthologues and 10 paralogues. Low expression observed in reference dataset.

功能概要

ABCB5 属于完整膜蛋白的 ATP 结合盒 (ABC) 转运蛋白超家族。这些蛋白质参与 ATP 依赖性跨膜转运，从小离子、糖和肽到更复杂的有机分子等结构多样的分子 (Chen 等人，2005 [PubMed 15760339]) 。[OMIM 提供，2008 年 3 月]

ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and Peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]

ABCB5 基因产物(4)

mRNA Protein Name
NM_001163941.2 NP_001157413.1 ATP-binding cassette sub-family B member 5 isoform 1
NM_001163942.2 NP_001157414.1 ATP-binding cassette sub-family B member 5 isoform 3
NM_001163993.3 NP_001157465.1 ATP-binding cassette sub-family B member 5 isoform 4
NM_178559.6 NP_848654.3 ATP-binding cassette sub-family B member 5 isoform 2

ABCB5 蛋白结构

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (48 - 334)

ABC_tran

ABC_tran: ABC transporter (404 - 553)

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (693 - 967)

ABC_tran

ABC_tran: ABC transporter (1033 - 1184)

  • 0
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  • 1000
  • 1257 a.a.
蛋白主名 其他名称

ATP-binding cassette sub-family B member 5

ABCB5 P-gp

重组 ABCB5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7621 ABCB5 Protein, Human (Trx) Q2M3G0 (I586-V692) ≥95%

关联疾病

疾病名称 别名
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Conjunctival Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Conjunctiva

Conjunctival Epidermoid Carcinoma

Invasive Squamous Cell Carcinoma Of The Conjunctiva

Ocular Surface Squamous Neoplasia
Cardiomyopathy, Dilated, 1o

Dilated Cardiomyopathy 1o

CMD1O

Dilated Cardiomyopathy With Ventricular Tachycardia

Cardiomyopathy, Dilated, With Ventricular Tachycardia

Cardiomyopathy, Dilated 1o

Cardiomyopathy, Dilated, Type 1o
Recessive Dystrophic Epidermolysis Bullosa

Autosomal Recessive Dystrophic Epidermolysis Bullosa Generalisata Gravis

Autosomal Recessive Dystrophic Epidermolysis Bullosa, Hallopeau-Siemens Type

Rdeb, Hallopeau-Siemens Type

Severe Generalized Rdeb

Severe Generalized Recessive Dystrophic Epidermolysis Bullosa

Rdeb Generalisata Gravis

Rdeb, Severe Generalized

Rdeb-Sev Gen

Recessive Dystrophic Epidermolysis Bullosa, Severe Generalized

Hallopeau-Siemens Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00052 ABCB5 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ABCB5 VGNC VGNC:49905
Felis catus ABCB5 VGNC VGNC:69335
Mus musculus ABCB5 MGD MGI:1924956
Macaca mulatta ABCB5 VGNC VGNC:80321
Bos taurus ABCB5 VGNC VGNC:25464
Rattus norvegicus ABCB5 RGD RGD:1566342
Others ABCB5 NCBI
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