IL3RA - interleukin 3 receptor subunit alpha Gene

中文名称：白介素 3 受体亚基 α

种属: Homo sapiens

同用名: IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra

基因 ID: 3563 | 基因类型: protein coding

关于 IL3RA

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:1,336,785-1,382,689 (from NCBI)

This gene has 3 transcripts (splice variants), 593 orthologues and 23 paralogues. Ubiquitous expression in lung (RPKM 8.7), lymph node (RPKM 8.6) and 24 other tissues.

功能概要

该基因编码的蛋白质是异二聚体细胞因子受体的白细胞介素 3 特异性亚基。该受体由白细胞介素 3 (IL3) 、集落刺激因子 2 (CSF2/GM-CSF) 和白细胞介素 5 (IL5) 受体共享的配体特异性 α 亚基和信号转导 β 亚基组成。该蛋白与 IL3 的结合取决于 β 亚基。 β 亚基被配体结合激活，是 IL3 生物活性所必需的。该基因和编码集落刺激因子 2 受体 α 链 (CSF2RA) 的基因在 X 或 Y 染色体上的 XY 假常染色体区域形成细胞因子受体基因簇。已发现编码不同亚型的可变剪接转录变体。[RefSeq 提供，2012 年 6 月]

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

IL3RA 基因产物(2)

mRNA	Protein	Name
NM_001267713.2	NP_001254642.1	interleukin-3 receptor subunit alpha isoform 2 precursor
NM_002183.4	NP_002174.1	interleukin-3 receptor subunit alpha isoform 1 precursor

IL3RA 蛋白结构

IL6Ra-bind

0
100
200
300
378 a.a.

蛋白主名

其他名称

interleukin-3 receptor subunit alpha

CD123 antigen

重组 IL3RA 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70468	IL-3R alpha/CD123 Protein, Human (HEK293, His)	P26951 (T19-R305)	≥95%
HY-P72349	IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, Fc-Avi)	P26951 (T19-R305)	≥95%
HY-P73213	IL-3R alpha/CD123 Protein, Human (HEK293, His-Fc)	P26951 (M1-R305)	≥95%
HY-P700747	IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, His-Avi)	P26951-1 (T19-R305)	≥95%

关联疾病

疾病名称

别名

Diphtheria

Corynebacterium Infections	Corynebacterium Infection
Diphtherial Infection	Infection Due To Corynebacterium Diphtheriae

Hairy Cell Leukemia

Hcl-V	Hairy Cell Leukemia Variant
Hairy Cell Leukaemia Variant	Hcl
Leukemic Reticuloendotheliosis	Leukemic Reticuloendotheliosis Variant
Prolymphocytic Variant Of Hcl	Prolymphocytic Variant Of Hairy Cell Leukemia
Leukemia Hairy Cell	Leukemia, Hairy Cell
Leukaemic Reticuloendotheliosis	Lre - [Leukemic Reticuloendotheliosis]
Hairy-Cell Leukaemia, Nos	Hcl - [Hairy Cell Leukaemia]
Hairy-Cell Leukaemia Without Mention Of Remission

Acute Leukemia

Stem Cell Leukaemia	Stem Cell Leukemia
Acute Leukemias	Acute Undifferentiated Leukemia
Undifferentiated Leukemia	Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission
Blast Cell Leukaemia	Blast Leukaemia
Blastic Leukaemia	Undifferentiated Leukaemia

Chronic Urticaria

Urticaria Chronic	Chronic Spontaneous Urticaria
Chronic Ordinary Urticaria

Pulmonary Alveolar Proteinosis

Mastocytosis

Mast Cell Disease	Mast Cell Hyperplasia
Urticaria Pigmentosa	Malignant Mastocytoma
Malignant Mast Cell Tumours	Malignant Mastocytosis

Acute Basophilic Leukemia

Keratoacanthoma

Ka - [Keratoacanthoma]

Well-Differentiated Squamous Cell Carcinoma

Hematologic Cancer

Hematologic Neoplasm	Hematologic Neoplasms
Hematologic Malignancies	Blood Cancer
Hematologic Malignancy	Hematological Tumors
Hematopoietic And Lymphoid System Tumor	Hematopoietic Cancer
Hematopoietic Neoplasm	Hematopoietic Tumors
Malignant Hematopoietic Neoplasm	Liquid Tumor
Hematopoietic Neoplasms

Refractory Hairy Cell Leukemia

Amoxicillin Allergy

Oxirane Allergy

Ethylene Oxide Allergy

Eto Allergy

Capillary Disease

Disease Of Capillaries

Refractory Hematologic Cancer

Refractory Hematologic Malignancy

Capillary Leak Syndrome

Systemic Capillary Leak Syndrome	Clarkson Disease
Capillary Leak Syndrome With Monoclonal Gammopathy	Scls
Periodic Systemic Capillary Leak Syndrome	Capillary Hyperpermeability Syndrome
Idiopathic Capillary Leak Syndrome

Spleen Cancer

Spleen Neoplasm	Splenic Neoplasm
Splenic Neoplasms	Malignant Splenic Tumor
Malignant Tumour Of Spleen	Tumor Of Spleen
Malignant Neoplasm Of Spleen

Splenic Marginal Zone Lymphoma

Smzl	Splenic Marginal Zone B-Cell Lymphoma

Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous

Diclofenac Allergy

Voltaren Allergy

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Chlorhexidine Allergy

Chronic Myelomonocytic Leukemia

Leukemia, Myelomonocytic, Chronic	Cmml
Leukemia Myelomonocytic Chronic	Cmml - [Chronic Myelomonocytic Leukaemia]
Chronic Myelomonocytic Leukaemia Without Mention Of Remission	Chronic Monocytic Leukaemia
Chronic Monocytoid Leukaemia

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Pancytopenia

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06764	IL3RA Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	IL3RA	MGD	MGI:96553
Canis familiaris	IL3RA	VGNC	VGNC:54959
Rattus norvegicus	IL3RA	RGD	RGD:628728
Bos taurus	IL3RA	VGNC	VGNC:106780

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

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