IL-3R alpha/CD123 蛋白, Human (Biotinylated, HEK293, Fc-Avi)

FITC-tagged IL-3R α/CD123 is a cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes, and B lymphocytes, regulating their production and differentiation. IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived IL-3R alpha/CD123 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of IL-3R alpha/CD123 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 287 a.a., with molecular weight of 80-100 kDa.

IL-3R α/CD123 蛋白作为 IL3 的细胞表面受体，在造血祖细胞、单核细胞和 B 淋巴细胞上表达，控制造血祖细胞向谱系限制细胞的产生和分化。在配体刺激后，它迅速与 IL3RB 发生异二聚化，导致效应蛋白（包括 JAK2 和 PI3K）磷酸化和激活。这些激活的途径在信号细胞增殖和分化中发挥着至关重要的作用。JAK2 激活进一步启动 STAT5 介导的转录程序，有助于细胞功能的调节。该受体与其配体 IL3 相互作用，形成由 α 和 β 亚基组成的异二聚体。值得注意的是，IL3、IL5 和 GM-CSF 受体共有 β 亚基。

Human

HEK293

C-Avi;C-hFc

P26951 (T19-R305)

3563  [NCBI]

TKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSMPAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFLSCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSSHILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYELQIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGANTRAWR

80-100 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.