2. Gene
  3. LAIR1 - leukocyte associated immunoglobulin like receptor 1 Gene

LAIR1 - leukocyte associated immunoglobulin like receptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白细胞相关免疫球蛋白样受体 1

种属: Homo sapiens

同用名: CD305; LAIR-1

基因 ID: 3903 | 基因类型: protein coding

关于 LAIR1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,351,384-54,376,088 (from NCBI)

This gene has 23 transcripts (splice variants), 1 gene allele and 66 orthologues. Broad expression in bone marrow (RPKM 19.6), appendix (RPKM 16.8) and 17 other tissues.

功能概要

由该基因编码的蛋白质是一种在外周单核细胞 (包括自然杀伤细胞、T 细胞和 B 细胞) 上发现的抑制性受体。抑制性受体调节免疫反应以防止被识别为自身的细胞裂解。该基因是免疫球蛋白超家族和白细胞相关抑制受体家族的成员。该基因映射到称为白细胞受体簇的 19q13.4 区域，该区域至少包含 29 个编码免疫球蛋白超家族白细胞表达受体的基因。编码的蛋白质已被确定为酪氨酸磷酸酶 SHP-1 的锚点，并可能诱导髓样白血病中的细胞死亡。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 1 月]

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine Phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

LAIR1 基因产物(6)

mRNA Protein Name
NM_001289023.3 NP_001275952.2 leukocyte-associated immunoglobulin-like receptor 1 isoform c precursor
NM_001289025.3 NP_001275954.2 leukocyte-associated immunoglobulin-like receptor 1 isoform e precursor
NM_001289026.3 NP_001275955.2 leukocyte-associated immunoglobulin-like receptor 1 isoform f
NM_001289027.3 NP_001275956.2 leukocyte-associated immunoglobulin-like receptor 1 isoform g
NM_002287.6 NP_002278.2 leukocyte-associated immunoglobulin-like receptor 1 isoform a precursor
NM_021706.5 NP_068352.2 leukocyte-associated immunoglobulin-like receptor 1 isoform b precursor

LAIR1 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (29 - 120)

  • 0
  • 100
  • 200
  • 287 a.a.
蛋白主名 其他名称

leukocyte-associated immunoglobulin-like receptor 1

immunoglobulin heavy chain variable region

重组 LAIR1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72390 LAIR1 Protein, Human (Biotinylated, HEK293, Avi-His) Q6GTX8 (Q22-H163) ≥95%
HY-P72529 LAIR1 Protein, Human (HEK293, His) Q6GTX8 (Q22-H163) ≥95%
HY-P74784 LAIR1 Protein, Human (144a.a, HEK293, hFc) Q6GTX8 (Q22-Y165) ≥95%
HY-P74785 LAIR1 Protein, Human (Biotinylated, 165a.a, HEK293, His-Avi) Q6GTX8 (M1-Y165) ≥95%
HY-P74786 LAIR1 Protein, Human (Biotinylated, 144a.a, HEK293, His) Q6GTX8 (Q22-Y165) ≥95%
HY-P74787 LAIR1 Protein, Human (165a.a, HEK293, His) Q6GTX8 (M1-Y165) ≥95%
HY-P78476 LAIR1 Protein, Human (HEK293, His-Avi) Q6GTX8 (Q22-H163) ≥95%

关联疾病

疾病名称 别名
Chronic Active Epstein-Barr Virus Infection

Caebv Infection

Cebv

Chronic Active Epstein-Barr Disease
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07494 LAIR1 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus LAIR1 MGD MGI:105492
Felis catus LAIR1 VGNC VGNC:109515
Rattus norvegicus LAIR1 RGD RGD:1560048
Bos taurus LAIR1 VGNC VGNC:109390
Macaca mulatta LAIR1 NCBI
Others LAIR1 NCBI
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