NOX3 - NADPH oxidase 3 Gene

中文名称：NADPH 氧化酶 3

种属: Homo sapiens

同用名: MOX-2; GP91-3

关于 NOX3

功能概要

该基因编码 NADPH 氧化酶的 NOX 家族成员。这些酶具有产生超氧化物和其他活性氧 (ROS) 以及跨质膜传输电子的能力。家族成员产生的 ROS 涉及许多生物学功能，包括宿主防御、蛋白质翻译后加工、细胞信号传导、基因表达调节和细胞分化。该基因编码的蛋白质主要在内耳中表达，并参与耳石/耳石的生物发生，耳石是内耳的晶体结构，参与重力感知。[RefSeq 提供，2009 年 5 月]

This gene encodes a member of the NOX family of NADPH oxidases. These Enzymes have the capacity to generate superoxide and other Reactive Oxygen Species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009]