1. Metabolic Enzyme/Protease
  2. NADPH Oxidase
  3. APX-115

APX-115 (Synonyms: Ewha-18278)

目录号: HY-120801
产品使用指南

APX-115 (Ewha-18278) 是一种有效的,口服活性的,非选择性 Nox 抑制剂,对 Nox1Nox2Nox4 的 Ki 值分别为 1.08 μM,0.57 μM 和 0.63 μM。APX-115 可以保护卵巢切除术引起的骨质疏松症和 2 型糖尿病引起的肾损伤。APX-115 可有效预防糖尿病小鼠的肾损伤,如白蛋白尿,肾小球肥大,肾小管损伤,足细胞损伤,纤维化和炎症以及氧化应激。

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APX-115 Chemical Structure

APX-115 Chemical Structure

CAS No. : 1395946-75-4

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Description

APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 can protect ovariectomy-induced osteoporosis and type 2 diabetes-induced renal injury. APX-115 effectively prevents kidney injury such as albuminuria, glomerular hypertrophy, tubular injury, podocyte injury, fibrosis, and inflammation as well as oxidative stress in diabetic mice[1].

IC50 & Target

Ki: 1.08 μM (Nox1), 0.57 μM (Nox2) and 0.63 μM (Nox4)[1]

Molecular Weight

315.80

Formula

C₁₇H₁₈ClN₃O

CAS No.

1395946-75-4

SMILES

OC1=C(CCC)C(C2=CC=CC=C2)=NN1C3=NC=CC=C3.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
APX-115
目录号:
HY-120801
需求量:

APX-115

Cat. No.: HY-120801