TNFRSF12A - TNF receptor superfamily member 12A Gene

中文名称：TNF 受体超家族成员 12A

种属: Homo sapiens

同用名: FN14; CD266; TWEAKR

基因 ID: 51330 | 基因类型: protein coding

关于 TNFRSF12A

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,020,368-3,022,383 (from NCBI)

This gene has 7 transcripts (splice variants) and 88 orthologues. Ubiquitous expression in gall bladder (RPKM 21.3), liver (RPKM 18.8) and 23 other tissues.

功能概要

参与外源性凋亡信号通路的正向调节和伤口愈合的调节。预测位于细胞表面和褶皱处。预计在质膜上有活性。 [由基因组资源联盟提供，2022 年 4 月]

Involved in positive regulation of extrinsic apoptotic signaling pathway and regulation of wound healing. Predicted to be located in cell surface and ruffle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TNFRSF12A 基因产物(1)

mRNA	Protein	Name
NM_016639.3	NP_057723.1	tumor necrosis factor receptor superfamily member 12A precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11728344	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of apoptotic process	IDA IDA: 通过直接分析推断	21525013	GOA
involved in positive regulation of extrinsic apoptotic signaling pathway	IMP IMP: 通过突变表型推断	21525013	GOA
involved in regulation of wound healing	IDA IDA: 通过直接分析推断	11728344	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNFRSF12A 蛋白结构

stn_TNFRSF12A

0
100
129 a.a.

蛋白主名

其他名称

tumor necrosis factor receptor superfamily member 12A

FGF-inducible 14

TNFRSF12A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TNFRSF12A	Q9NP84	TRAF2	Homo sapiens	Q12933	Anti Bait CoIP	21525013
种属内	TNFRSF12A	Q9NP84	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
种属内	TNFRSF12A	Q9NP84	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
种属内	TNFRSF12A	Q9NP84	BIRC2	Homo sapiens	Q13490	Anti Bait CoIP	21525013
种属内	TNFRSF12A	Q9NP84	SLC30A2	Homo sapiens	Q9BRI3	Y2H Array	31515488
种属内	TNFRSF12A	Q9NP84	SLC30A2	Homo sapiens	Q9BRI3	Y2H Array	25416956
种属内	TNFRSF12A	Q9NP84	SLC30A2	Homo sapiens	Q9BRI3	Y2H Array	32296183
种属内	TNFRSF12A	Q9NP84	SLC30A2	Homo sapiens	Q9BRI3	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TNFRSF12A 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72434	TNFRSF12A Protein, Human (HEK293, Fc)	Q9NP84-1 (E28-W79)	≥95%

TNFRSF12A 抗体

目录号	产品名	应用	反应物种
HY-P82931	CD266 Antibody (YA2676)	WB, IHC-P, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P99361	Enavatuzumab	Inhibitor	≥99.0%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14803	TNFRSF12A Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17480	Tnfrsf12a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23938	Tnfrsf12a Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P991433	BIIB036	Activator	/	否
HY-P991439	BIIB023	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	TNFRSF12A	VGNC	VGNC:47656
Bos taurus	TNFRSF12A	VGNC	VGNC:36162
Mus musculus	TNFRSF12A	MGD	MGI:1351484
Macaca mulatta	TNFRSF12A	VGNC	VGNC:99623
Rattus norvegicus	TNFRSF12A	RGD	RGD:631329
Felis catus	TNFRSF12A	VGNC	VGNC:107825
Others	TNFRSF12A	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TNFRSF12A - TNF receptor superfamily member 12A Gene

关于 TNFRSF12A

功能概要

TNFRSF12A 基因产物(1)

TNFRSF12A 蛋白结构

TNFRSF12A 蛋白互作信息

重组 TNFRSF12A 蛋白

TNFRSF12A 抗体

关联疾病

直系同源

热门区域

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TNFRSF12A - TNF receptor superfamily member 12A Gene

关于 TNFRSF12A

功能概要

TNFRSF12A 基因产物(1)

TNFRSF12A 蛋白结构

TNFRSF12A 蛋白互作信息

重组 TNFRSF12A 蛋白

TNFRSF12A 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z