2. Apoptosis
  3. TNF Receptor
  4. Enavatuzumab

Enavatuzumab  (Synonyms: 依那妥组单抗; PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab))

目录号: HY-P99361 纯度: ≥95.0%
COA

摩尔计算器

Enavatuzumab (PDL192; ABT-361) 是一种人源化 IgG1 单克隆抗体，靶向 TNF 样细胞凋亡弱诱导剂受体 (TWEAK)。TWEAK (Fn14; TNFRSF12A) 是 TWEAK 受体 (TweakR) 的天然配体，可刺激多种细胞反应。Enavatuzumab 通过直接的 TweakR 信号和抗体依赖性细胞介导的细胞毒性 (ADCC) 诱导肿瘤生长抑制。Enavatuzumab 可以主动募集和激活骨髓效应细胞来杀死肿瘤细胞。Enavatuzumab 在体外和体内抑制各种人类 TweakR 阳性癌细胞系和异种移植物的生长。

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Enavatuzumab Chemical Structure

Enavatuzumab Chemical Structure

CAS No. : 1062149-33-0

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5 mg ￥7500
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Enavatuzumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo [1] [2].

体外研究
(In Vitro)

Enavatuzumab (0.1-1000 ng/mL; 4 小时) 在体外诱导效应细胞活化和肿瘤细胞杀伤[1]。
Enavatuzumab (10μg/mL; 24 小时) 导致免疫效应细胞向 SN12C 和 A375 肿瘤细胞的迁移显着增加[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Enavatuzumab 相关抗体:

Cell Viability Assay[1]

Cell Line: Renal carcinoma cell line SN12C, the melanoma cell line A375, the colorectal cancer cell lines HCT116 and DLD-1
Concentration: 0.1, 1, 10, 100, 1000 ng/mL
Incubation Time: 4 hours
Result: Showed potent tumor cell killing on all TweakR-positive tumor cells tested.
体内研究
(In Vivo)

Enavatuzumab (10mg/kg; 腹腔注射; 每周 3 次; 6, 7 或者 9 剂) 对不同的异种移植肿瘤表现出不同的抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week old SCID mice with SN12C or HCT116 or DLD-1 or A375 tumors[1]
Dosage: 10 mg/kg
Administration: IP; three times per week; 6 doses (DLD-1 model), 7 doses (SN12C model), 9 doses (A375 or HCT116 model)
Result: Some TweakR-expressing cells, such as SN12C and A375, were sensitive in vivo and in vitro.
Some TweakR-expressing cell lines, such as HCT116 and DLD-1, were not sensitive to enavatuzumab treatment in vivo, though both cell lines were effectively killed via ADCC in vitro.
Up-regulated the activation markers on splenocytes in SN12C tumor-bearing mice.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

依那妥组单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Enavatuzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enavatuzumab1062149-33-0PDL192 ABT-361 Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)依那妥组单抗PDL 192PDL-192ABT361ABT 361ABT-361TNF ReceptorTumor Necrosis Factor ReceptorTNFRIgG1antibodyTNF-like weak inducer of apoptosisTWEAKFn14TNFRSF12ATweakRADCCmyeloid effectorcancerInhibitorinhibitorinhibit

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