2. 重组蛋白
  3. Cytokines and Growth Factors CD Antigens
  4. TNF Superfamily Epithelial cell CD Proteins Endothelial cell CD Proteins
  5. TNF Receptor Superfamily TWEAK R/CD266
  6. TWEAK R/CD266
  7. TNFRSF12A 蛋白, Human

TNFRSF12A 蛋白是 TNFSF12/TWEAK 的受体，在特定细胞类型中充当弱凋亡诱导剂。它还促进血管生成、内皮细胞增殖，并可能调节细胞对基质蛋白的粘附。与 TRAF1、TRAF2 和潜在的 TRAF3 的关联强调了它参与多种细胞信号传导途径。TNFRSF12A 蛋白, Human 是重组的 TNFRSF12A 蛋白，由 E. coli 表达，不带标签。

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SPR 检测服务   重组蛋白定制服务

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描述

TNFRSF12A Protein, the receptor for TNFSF12/TWEAK, acts as a weak apoptosis inducer in specific cell types. It also promotes angiogenesis, endothelial cell proliferation, and may modulate cellular adhesion to matrix proteins. Association with TRAF1, TRAF2, and potentially TRAF3 underscores its involvement in diverse cellular signaling pathways. TNFRSF12A Protein, Human is the recombinant human-derived TNFRSF12A protein, expressed by E. coli , with tag free.
研究背景

TNFRSF12A 蛋白充当 TNFSF12/TWEAK 的受体，并且在某些细胞类型中充当细胞凋亡的弱诱导剂。此外，它在促进血管生成和内皮细胞增殖方面发挥作用，并且可以调节细胞对基质蛋白的粘附。该蛋白与 TRAF1 和 TRAF2 相关，并且可能与 TRAF3 相关，表明它参与多种细胞信号传导途径。
种属

Human
表达系统

E. coli
标签

Tag Free
蛋白编号

Q9NP84-1 (E28-P80)
基因 ID
蛋白结构
N-term
TNFRSF12A (E28-P80)
Accession # Q9NP84-1
C-term
中文名
肿瘤坏死因子受体 SF12A 蛋白
同用名
CD 266; CD266; CD266 antigen; FGF inducible 14; FGF-inducible 14; Fibroblast growth factor inducible immediate early response protein 14; Fibroblast growth factor-inducible immediate-early response protein 14; FN 14; FN14; TNFRSF 12A; TNFRSF12A; TNR12_HUMAN; Tumor necrosis factor receptor superfamily member 12A; TWEAK R; Tweak receptor; Tweak-receptor; TweakR
氨基酸序列

EQAPGTAPCSRGSSWSADLDKCMDCASCRARPHSDFCLGCAAAPPAPFRLLWP

预测分子量
5.6 kDa
分子量

Approximately 8 kDa, based on SDS-PAGE under reducing conditions.
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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