Ppm1d - protein phosphatase 1D magnesium-dependent, delta isoform Gene

种属: Mus musculus

同用名: Wip1

关于 Ppm1d

功能概要

Predicted to enable mitogen-activated protein kinase binding activity and protein serine/threonine Phosphatase activity. Involved in DNA methylation and heterochromatin assembly. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; G2/M transition of mitotic cell cycle; and response to bacterium. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including adrenal gland; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human PPM1D (protein Phosphatase, Mg2+/Mn2+ dependent 1D). [provided by Alliance of Genome Resources, Apr 2022]