2. Gene
  3. SHLD2 - shieldin complex subunit 2 Gene

SHLD2 - shieldin complex subunit 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：shieldin 复合亚基 2

种属: Homo sapiens

同用名: RINN2; FAM35A; FAM35A1; bA163M19.1

基因 ID: 54537 | 基因类型: protein coding

关于 SHLD2

Cytogenetic location: 10q23.2 Genomic coordinates (GRCh38): 10:87,094,473-87,191,465 (from NCBI)

This gene has 3 transcripts (splice variants) and 190 orthologues. Ubiquitous expression in kidney (RPKM 20.9), thyroid (RPKM 14.9) and 25 other tissues.

功能概要

通过同源重组参与双链断裂修复的负调控；通过非同源末端连接对双链断裂修复进行正调控；和同种型转换的正向调节。位于细胞核和双链断裂位点。 [由基因组资源联盟提供，2022 年 4 月]

Involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Located in nucleus and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

SHLD2 基因产物(17)

mRNA Protein Name
NM_001330112.2 NP_001317041.1 shieldin complex subunit 2 isoform 1
NM_001377158.1 NP_001364087.1 shieldin complex subunit 2 isoform 2
NM_001377159.1 NP_001364088.1 shieldin complex subunit 2 isoform 2
NM_001377160.1 NP_001364089.1 shieldin complex subunit 2 isoform 3
NM_001377161.1 NP_001364090.1 shieldin complex subunit 2 isoform 4
NM_001377162.1 NP_001364091.1 shieldin complex subunit 2 isoform 5
NM_001377163.1 NP_001364092.1 shieldin complex subunit 2 isoform 6
NM_001377164.1 NP_001364093.1 shieldin complex subunit 2 isoform 7
NM_001377165.1 NP_001364094.1 shieldin complex subunit 2 isoform 7
NM_001377166.1 NP_001364095.1 shieldin complex subunit 2 isoform 8
NM_001377167.1 NP_001364096.1 shieldin complex subunit 2 isoform 8
NM_001377168.1 NP_001364097.1 shieldin complex subunit 2 isoform 8
NM_001377169.1 NP_001364098.1 shieldin complex subunit 2 isoform 9
NM_001377170.1 NP_001364099.1 shieldin complex subunit 2 isoform 10
NM_001377171.1 NP_001364100.1 shieldin complex subunit 2 isoform 11
NM_001377172.1 NP_001364101.1 shieldin complex subunit 2 isoform 12
NM_019054.3 NP_061927.2 shieldin complex subunit 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
29656893 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
29656893 GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining IDA
IDA: 通过直接分析推断
29656893 GOA
involved in positive regulation of isotype switching IDA
IDA: 通过直接分析推断
29656893 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome IDA
IDA: 通过直接分析推断
29656893 GOA
located in nucleus IDA
IDA: 通过直接分析推断
29789392 GOA
located in site of double-strand break IDA
IDA: 通过直接分析推断
29656893 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

shieldin complex subunit 2

RINN1-REV7-interacting novel NHEJ regulator 2

SHLD2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SHLD2 Q86V20 SHLD1 Homo sapiens Q8IYI0
Anti Tag CoIP
29656893
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-139289 ART812 99.90% 否
HY-RS12874 SHLD2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SHLD2 VGNC VGNC:40677
Felis catus SHLD2 VGNC VGNC:65128
Mus musculus SHLD2 MGD MGI:1922948
Rattus norvegicus SHLD2 RGD RGD:1565067
Bos taurus SHLD2 VGNC VGNC:28808
Macaca mulatta SHLD2 VGNC VGNC:106101
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