1. Gene
  2. CDCA8 - cell division cycle associated 8 Gene

CDCA8 - cell division cycle associated 8 Gene

中文名称:细胞分裂周期相关 8

种属: Homo sapiens

同用名: BOR; DasraB; MESRGP; BOREALIN

基因 ID: 55143 | 基因类型: protein coding

关于 CDCA8

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:37,692,516-37,709,719 (from NCBI)

This gene has 2 transcripts (splice variants) and 210 orthologues. Biased expression in testis (RPKM 14.3), bone marrow (RPKM 12.4) and 13 other tissues.

功能概要

该基因编码染色体乘客复合体的一个组成部分。该复合物是有丝分裂和细胞分裂的重要调节因子。这种蛋白质受细胞周期调节,是染色质诱导的微管稳定和纺锤体形成所必需的。交替剪接导致多个转录本变体。该基因的假基因存在于 7、8 和 16 号染色体上。[RefSeq 提供,2013 年 4 月]

This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

CDCA8 基因产物(2)

mRNA Protein Name
NM_001256875.2 NP_001243804.1 borealin
NM_018101.4 NP_060571.1 borealin

CDCA8 蛋白结构

Nbl1_Borealin_N

Nbl1_Borealin_N: Nbl1 / Borealin N terminal (19 - 76)

Borealin

Borealin: Cell division cycle-associated protein 8 (163 - 277)

  • 0
  • 100
  • 200
  • 280 a.a.
蛋白主名 其他名称

borealin

Dasra B

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CDCA8 RGD RGD:1566306
Mus musculus CDCA8 MGD MGI:1196274
Bos taurus CDCA8 VGNC VGNC:27088
Macaca mulatta CDCA8 VGNC VGNC:70714
Felis catus CDCA8 VGNC VGNC:60670
Canis familiaris CDCA8 VGNC VGNC:39017