2. Gene
  3. PPP3CC - protein phosphatase 3 catalytic subunit gamma Gene

PPP3CC - protein phosphatase 3 catalytic subunit gamma Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白磷酸酶 3 催化亚基 γ

种属: Homo sapiens

同用名: CNA3; CALNA3; PP2Bgamma

基因 ID: 5533 | 基因类型: protein coding

关于 PPP3CC

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,441,078-22,541,125 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 12 paralogues. Broad expression in testis (RPKM 12.3), lymph node (RPKM 5.3) and 24 other tissues.

功能概要

钙调神经磷酸酶是一种钙依赖性、钙调蛋白刺激的蛋白磷酸酶，参与多巴胺能信号转导的下游调节。钙调神经磷酸酶由调节亚基和催化亚基组成。由该基因编码的蛋白质代表已发现的神经钙蛋白调节亚基之一。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2011 年 9 月]

Calcineurin is a calcium-dependent, calmodulin-stimulated protein Phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for Calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

PPP3CC 基因产物(3)

mRNA Protein Name
NM_001243974.2 NP_001230903.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 1
NM_001243975.2 NP_001230904.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 3
NM_005605.5 NP_005596.2 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium-dependent protein serine/threonine phosphatase activity IDA
IDA: 通过直接分析推断
26429887 GOA
enables calmodulin-dependent protein phosphatase activity IDA
IDA: 通过直接分析推断
19154138 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcineurin-NFAT signaling cascade IDA
IDA: 通过直接分析推断
19154138 GOA
involved in protein dephosphorylation IDA
IDA: 通过直接分析推断
19154138 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19154138 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP3CC 蛋白结构

Metallophos

Metallophos: Calcineurin-like phosphoesterase (80 - 280)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 512 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

CAM-PRP catalytic subunit

PPP3CC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PPP3CC P48454 SPATA33 Homo sapiens Q96N06
Validated Y2H
32296183
种属内
PPP3CC P48454 UNC119 Homo sapiens Q13432
Validated Y2H
32296183
种属内
PPP3CC P48454 AMPH Homo sapiens P49418
Y2H Array
25416956
种属内
PPP3CC P48454 AMPH Homo sapiens P49418
Validated Y2H
25416956
种属内
PPP3CC P48454 PPP3R1 Homo sapiens P63098
Anti Tag CoIP
28514442
种属内
PPP3CC P48454 PPP3R1 Homo sapiens P63098
Validated Y2H
32296183
种属内
PPP3CC P48454 PPP3R1 Homo sapiens P63098
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Melancholia
Schizophrenia 11

Sczd11

Schizophrenia Susceptibility Locus, Chromosome 10q-Related
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Schizophrenia 6

SCZD6

Schizophrenia Susceptibility Locus, Chromosome 8p-Related

Schizophrenia, Type 6
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11025 PPP3CC Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PPP3CC VGNC VGNC:69021
Rattus norvegicus PPP3CC RGD RGD:621616
Mus musculus PPP3CC MGD MGI:107162
Canis familiaris PPP3CC VGNC VGNC:44920
Macaca mulatta PPP3CC VGNC VGNC:76383
Bos taurus PPP3CC VGNC VGNC:33267
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