SRGN - serglycin Gene

中文名称：血清甘氨酸

种属: Homo sapiens

同用名: PPG; PRG; PRG1

关于 SRGN

功能概要

该基因编码一种被称为造血细胞颗粒蛋白多糖的蛋白质。储存在许多造血细胞分泌颗粒中的蛋白多糖也含有抗蛋白酶肽核心，这可能对中和水解酶很重要。发现这种编码的蛋白质与颗粒酶和穿孔素的大分子复合物相关，可作为颗粒介导的细胞凋亡的介质。已发现该基因的两种转录变体，其中只有一种是蛋白质编码的。[RefSeq 提供，2010 年 7 月]

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated Apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]