Serglycin/SRGN 蛋白, Human (HEK293, His-Myc)

Serine (SRGN) is essential for the formation of mast cell secretory granules and the storage of various compounds. It plays a crucial role in the storage of proteases in mast cells, including granzyme B in T lymphocytes, and contributes to the localization of neutrophil elastase. Serglycin/SRGN Protein, Human (HEK293, His-Myc) is the recombinant human-derived Serglycin/SRGN protein, expressed by HEK293 , with C-His, C-Myc labeled tag. The total length of Serglycin/SRGN Protein, Human (HEK293, His-Myc) is 158 a.a., with molecular weight of ~27 kDa.

Serglycin (SRGN) 在肥大细胞分泌颗粒的形成中发挥着重要作用，促进分泌囊泡内各种化合物的储存。它在结缔组织和粘膜肥大细胞中储存蛋白酶（包括 T 淋巴细胞中颗粒酶 B 的储存）中的作用强调了其不可或缺性。SRGN 还有助于中性粒细胞弹性蛋白酶在中性粒细胞天青粒细胞中的定位。此外，它还参与 MMP2 的加工，尤其是通过与颗粒酶 B 形成复合物，在颗粒介导的细胞凋亡中发挥关键作用。该复合物通过穿孔素递送至细胞，诱导细胞凋亡。除了参与细胞毒性细胞颗粒介导的过程之外，SRGN 还调节 TNF-α 的分泌，并可能影响蛋白酶的分泌。有趣的是，SRGN 对骨矿化表现出抑制作用，并与活化的 CD44 和颗粒酶 B (GZMB) 发生结合相互作用，突出了其在细胞过程和免疫调节中的多方面作用。

Human

HEK293

C-His;C-Myc

P10124 (M1-L158)

5552  [NCBI]

Approximately 27 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.