Sphk2 - sphingosine kinase 2 Gene

中文名称：鞘氨醇激酶 2

种属: Mus musculus

同用名: Sk2; Spk2

关于 Sphk2

功能概要

该基因编码一种激酶，可将鞘氨醇磷酸化为鞘氨醇-1-磷酸，参与细胞分化、运动和细胞凋亡。编码的蛋白质在维持细胞内 1-磷酸鞘氨醇水平方面发挥作用。该基因产物还可以增强不同细胞类型的细胞凋亡并抑制细胞增殖。在肥大细胞中，编码的蛋白质是钙流入、蛋白激酶 C 激活以及细胞因子产生和脱颗粒所必需的。可变剪接导致多个转录本变体。 [RefSeq 提供，2010 年 2 月]

This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and Apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances Apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]