2. Gene
  3. SPHK2 - sphingosine kinase 2 Gene

SPHK2 - sphingosine kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：鞘氨醇激酶 2

种属: Homo sapiens

同用名: SK 2; SK-2; SPK 2; SPK-2

基因 ID: 56848 | 基因类型: protein coding

关于 SPHK2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,619,506-48,630,405 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and 4 paralogues. Ubiquitous expression in kidney (RPKM 6.4), duodenum (RPKM 5.5) and 25 other tissues.

功能概要

该基因编码两种鞘氨醇激酶同工酶中的一种，可催化鞘氨醇磷酸化为鞘氨醇 1-磷酸。鞘氨醇 1-磷酸介导许多细胞过程，包括迁移、增殖和细胞凋亡，并且还通过促进血管生成和肿瘤发生在多种类型的癌症中发挥作用。编码的蛋白质可能在乳腺癌增殖和化学抗性中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and Apoptosis, and also plays a role in several types of Cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast Cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

SPHK2 基因产物(13)

mRNA Protein Name
XM_017027008.2 XP_016882497.1 sphingosine kinase 2 isoform X1
XM_011527134.2 XP_011525436.1 sphingosine kinase 2 isoform X3
XM_047439106.1 XP_047295062.1 sphingosine kinase 2 isoform X3
XM_011527133.2 XP_011525435.1 sphingosine kinase 2 isoform X2
NM_020126.5 NP_064511.2 sphingosine kinase 2 isoform a
NM_001204159.3 NP_001191088.1 sphingosine kinase 2 isoform a
NM_001204160.3 NP_001191089.1 sphingosine kinase 2 isoform c
NM_001204158.3 NP_001191087.1 sphingosine kinase 2 isoform b
XM_006723292.2 XP_006723355.1 sphingosine kinase 2 isoform X3
XM_047439107.1 XP_047295063.1 sphingosine kinase 2 isoform X4
NM_001243876.2 NP_001230805.1 sphingosine kinase 2 isoform d
XM_047439108.1 XP_047295064.1 sphingosine kinase 2 isoform X4
XM_017027010.3 XP_016882499.1 sphingosine kinase 2 isoform X4

SPHK2 蛋白结构

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (182 - 293)

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  • 654 a.a.
蛋白主名 其他名称

sphingosine kinase 2

关联疾病

疾病名称 别名
Dermatitis, Atopic, 7

ATOD7

Dermatitis, Atopic, Susceptibility To, 7

Atopic Dermatitis 7

Dermatitis, Atopic 7
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Ureteral Obstruction
Brachydactyly, Type E1

Brachydactyly Type E1

Brachydactyly Type E

BDE1

Brachydactyly, Type E

Bde

Type E Brachydactyly

Brachydactyly E1

Brachydactyly Syndrome Type E
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12892 SKI-178 Inhibitor 98.91% 否
HY-147282 Amgen-23 Inhibitor 99.00% 否
HY-148707 SphK1&2-IN-1 Inhibitor 99.33% 否
HY-151350 SphK2-IN-1 Inhibitor / 否
HY-150615 SphK1-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SPHK2 VGNC VGNC:35211
Rattus norvegicus SPHK2 RGD RGD:1307757
Macaca mulatta SPHK2 VGNC VGNC:77960
Mus musculus SPHK2 MGD MGI:1861380
Canis familiaris SPHK2 VGNC VGNC:46737
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