2. Gene
  3. Prkn - parkin RBR E3 ubiquitin protein ligase Gene

Prkn - parkin RBR E3 ubiquitin protein ligase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Park; Park2

基因 ID: 56816 | 基因类型: protein coding

关于 Prkn

功能概要

Enables protein kinase binding activity. Involved in several processes, including cellular response to amino acid stimulus; negative regulation of neuron death; and negative regulation of synaptic transmission. Acts upstream of or within negative regulation of neuron death. Located in several cellular components, including bounding membrane of organelle; membrane raft; and postsynaptic density. Colocalizes with mitochondrion. Used to study Parkinson's disease. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; and ovarian Cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Prkn 基因产物(1)

mRNA Protein Name
NM_020093.1 NP_064478.1 E3 ubiquitin-protein ligase parkin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16332688 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
28608965 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
12716939 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to L-glutamate IDA
IDA: 通过直接分析推断
25478815 RGD
involved in cellular response to L-glutamine IEP
IEP: 通过表达模式推断
28761318 RGD
involved in cellular response to hydrogen sulfide IDA
IDA: 通过直接分析推断
28608965 RGD
involved in cellular response to manganese ion IEP
IEP: 通过表达模式推断
19781568 RGD
involved in cellular response to oxidative stress IMP
IMP: 通过突变表型推断
23392669 RGD
involved in mitochondrial fragmentation involved in apoptotic process IMP
IMP: 通过突变表型推断
28761318 RGD
involved in mitochondrion localization IDA
IDA: 通过直接分析推断
20457763 RGD
involved in mitophagy IDA
IDA: 通过直接分析推断
20457763 RGD
involved in negative regulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
19033459 RGD
involved in negative regulation of mitochondrial fission IMP
IMP: 通过突变表型推断
24096089 RGD
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
20823226 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
28761318 RGD
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
23392669 RGD
involved in negative regulation of reactive oxygen species biosynthetic process IMP
IMP: 通过突变表型推断
24096089 RGD
involved in negative regulation of synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
19033459 RGD
involved in positive regulation of ATP biosynthetic process IMP
IMP: 通过突变表型推断
24096089 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
28673964 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
24096089 RGD
involved in positive regulation of mitochondrial membrane potential IMP
IMP: 通过突变表型推断
24096089 RGD
involved in positive regulation of mitophagy IMP
IMP: 通过突变表型推断
28608965 RGD
involved in protein localization to mitochondrion IDA
IDA: 通过直接分析推断
20457763 RGD
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
20457763 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: 通过直接分析推断
25316086 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
IEP: 通过表达模式推断
25316086 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
IMP: 通过突变表型推断
25316086 RGD
involved in response to corticosterone IEP
IEP: 通过表达模式推断
14663185 RGD
involved in response to curcumin IEP
IEP: 通过表达模式推断
28698153 RGD
involved in response to endoplasmic reticulum stress IEP
IEP: 通过表达模式推断
12415119 RGD
involved in response to muscle activity IEP
IEP: 通过表达模式推断
26678157 RGD
involved in response to unfolded protein IEP
IEP: 通过表达模式推断
12472897 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
12618056 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
12150907 RGD
located in axon IDA
IDA: 通过直接分析推断
28761318 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
12150907 RGD
located in cytosol IDA
IDA: 通过直接分析推断
20457763 RGD
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
12150907 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
25316086 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
25316086 RGD
located in intracellular vesicle IDA
IDA: 通过直接分析推断
12472897 RGD
located in mitochondrion IDA
IDA: 通过直接分析推断
20457763 RGD
located in neuron projection IDA
IDA: 通过直接分析推断
12925569 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
12472897 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
12925569 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
15480834 RGD
is active in presynapse IDA
IDA: 通过直接分析推断
15480834 RGD
located in presynapse IDA
IDA: 通过直接分析推断
12000718 RGD
located in synapse IDA
IDA: 通过直接分析推断
12150907 RGD
located in synaptic vesicle IDA
IDA: 通过直接分析推断
15480834 RGD
is active in synaptic vesicle membrane IDA
IDA: 通过直接分析推断
15480834 RGD
located in synaptic vesicle membrane IDA
IDA: 通过直接分析推断
11432972 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
12925569 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

E3 ubiquitin-protein ligase parkin

Parkinson disease (autosomal recessive, juvenile) 2, parkin

parkin RBR E3 ubiquitin protein ligase 2

parkin variant SV5DEL

parkinson protein 2, E3 ubiquitin protein ligase

Prkn 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Prkn Q9JK66 Ranbp2 Rattus norvegicus D4A054
Anti Bait CoIP
16332688
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11156 PRKN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18966 Prkn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25456 Prkn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkn NCBI NCBI:5071
Mus musculus Prkn NCBI NCBI:50873
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