ADGRB1 - adhesion G protein-coupled receptor B1 Gene

中文名称：粘附 G 蛋白偶联受体 B1

种属: Homo sapiens

同用名: BAI1; GDAIF

关于 ADGRB1

功能概要

血管生成由新血管生长的刺激剂和抑制剂之间的局部平衡控制，并在正常生理条件下受到抑制。血管生成已被证明对实体瘤的生长和转移至关重要。为了为其生长获得血液供应，肿瘤细胞具有强大的血管生成能力，并由于诱导物分泌增加和内源性负调节因子的产生减少而吸引新血管。 BAI1 在内含子中至少包含一个“功能性”p53 结合位点，其表达已被证明由野生型 p53 诱导。还有另外两个脑特异性血管生成抑制基因，命名为 BAI2 和 BAI3，它们与 BAI1 具有相似的组织特异性和结构，但只有 BAI1 受 p53 转录调控。 BAI1 被假定为分泌素受体家族的成员，一种血管生成抑制剂和胶质母细胞瘤的生长抑制剂[RefSeq 提供，2008 年 7 月]

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two Other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the Secretin Receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]