USP36 - ubiquitin specific peptidase 36 Gene

中文名称：泛素特异性肽酶 36

种属: Homo sapiens

同用名: DUB1

关于 USP36

功能概要

该基因编码肽酶 C19 或半胱氨酸蛋白酶泛素特异性蛋白酶家族的成员。该家族的成员从多泛素化蛋白质中去除泛素分子。编码的蛋白质可以去泛素化并稳定转录因子 c-Myc，也称为 MYC，这是一种已知在大多数人类癌症中上调的重要癌蛋白。编码的蛋白酶还可以调节自噬的激活。该基因在某些乳腺癌和肺癌中表现出升高的表达。[RefSeq 提供，2016 年 3 月]

This gene encodes a member of the peptidase C19 or Ubiquitin-Specific Protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of Autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]