2. Gene
  3. GPAM - glycerol-3-phosphate acyltransferase, mitochondrial Gene

GPAM - glycerol-3-phosphate acyltransferase, mitochondrial Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：3-磷酸甘油酰基转移酶，线粒体

种属: Homo sapiens

同用名: GPAT; GPAT1

基因 ID: 57678 | 基因类型: protein coding

关于 GPAM

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:112,149,865-112,227,677 (from NCBI)

This gene has 4 transcripts (splice variants), 203 orthologues and 2 paralogues. Biased expression in fat (RPKM 277.9), liver (RPKM 26.0) and 1 other tissue.

功能概要

该基因编码一种线粒体酶，该酶更倾向于将饱和脂肪酸作为合成甘油脂的底物。该代谢途径的第一步由编码的酶催化。这种酶存在两种形式，一种存在于线粒体中，一种存在于内质网中。已经描述了该基因的两个选择性剪接的转录物变体。[RefSeq 提供，2011 年 10 月]

This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

GPAM 基因产物(2)

mRNA Protein Name
NM_001244949.2 NP_001231878.1 glycerol-3-phosphate acyltransferase 1, mitochondrial precursor
NM_020918.6 NP_065969.3 glycerol-3-phosphate acyltransferase 1, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glycerol-3-phosphate O-acyltransferase activity EXP
EXP: 通过实验结果推断
18238778 GOA
enables glycerol-3-phosphate O-acyltransferase activity IMP
IMP: 通过突变表型推断
18238778 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in phosphatidylglycerol biosynthetic process IMP
IMP: 通过突变表型推断
19075029 GOA
involved in triglyceride biosynthetic process IDA
IDA: 通过直接分析推断
18238778 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPAM 蛋白结构

Acyltransferase

Acyltransferase: Acyltransferase (216 - 355)

  • 0
  • 200
  • 400
  • 600
  • 828 a.a.
蛋白主名 其他名称

glycerol-3-phosphate acyltransferase 1, mitochondrial

GPAT-1

GPAM 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GPAM Q9HCL2 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
种属内
GPAM Q9HCL2 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
种属内
GPAM Q9HCL2 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy

Berardinelli-Seip Syndrome

Brunzell Syndrome

Bscl

Generalized Lipodystrophy

Lipodystrophy, Congenital Generalized

Seip Syndrome

Total Lipodystrophy

Cgl

Lipoatrophic Diabetes

Lipodystrophy, Generalized, Congenital

Familial Generalized Lipodystrophy

Congenital Generalized Lipodystrophy Type 2

Lipoatrophic Diabetes Mellitus

Familial Partial Lipodystrophy, Type 2
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05615 GPAM Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20747 Gpam Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27259 Gpam Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus GPAM VGNC VGNC:62651
Rattus norvegicus GPAM RGD RGD:61847
Canis familiaris GPAM VGNC VGNC:41360
Macaca mulatta GPAM VGNC VGNC:73000
Mus musculus GPAM MGD MGI:109162
Bos taurus GPAM VGNC VGNC:29510
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