PTPRM - protein tyrosine phosphatase receptor type M Gene

中文名称：M 型蛋白酪氨酸磷酸酶受体

种属: Homo sapiens

同用名: RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU

关于 PTPRM

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 具有细胞外区域、单个跨膜区域和两个串联催化结构域，因此代表受体型 PTP。细胞外区域包含安眠蛋白-A5 抗原-PTP mu (MAM) 结构域、Ig 样结构域和四个纤连蛋白 III 型样重复序列。该 PTP 已被证明可通过与相邻细胞上该 PTP 的另一个分子相互作用来介导细胞间聚集。该 PTP 可以与支架蛋白 RACK1/GNB2L1 相互作用，这对于响应细胞间粘附的下游信号传导可能是必需的。可变剪接导致多个转录本编码不同的异构体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]