2. Gene
  3. Med12 - mediator complex subunit 12 Gene

Med12 - mediator complex subunit 12 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Mopa; OPA-1; 230kDa; Tnrc11; Trap230

基因 ID: 59024 | 基因类型: protein coding

关于 Med12

功能概要

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin binding activity; and transcription coactivator activity. Acts upstream of or within several processes, including Wnt signaling pathway; chordate embryonic development; and glial cell development. Part of mediator complex. Is expressed in brain. Human ortholog(s) of this gene implicated in FG syndrome; leiomyosarcoma; major depressive disorder; phobic disorder; and syndromic X-linked intellectual disorder Lujan-Fryns-type. Orthologous to human MED12 (mediator complex subunit 12). [provided by Alliance of Genome Resources, Apr 2022]

Med12 基因产物(1)

mRNA Protein Name
NM_021521.2 NP_067496.2 mediator of RNA polymerase II transcription subunit 12
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23575864 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
20720539 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
20720539 MGI
enables transcription coactivator activity IGI
IGI: 通过遗传相互作用推断
23575864 MGI
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
23575864 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Schwann cell development IMP
IMP: 通过突变表型推断
23575864 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IMP
IMP: 通过突变表型推断
20630950 MGI
acts upstream of or within axis elongation involved in somitogenesis IMP
IMP: 通过突变表型推断
20630950 MGI
acts upstream of or within embryonic brain development IMP
IMP: 通过突变表型推断
20589884 MGI
acts upstream of or within embryonic neurocranium morphogenesis IMP
IMP: 通过突变表型推断
20589884 MGI
acts upstream of or within embryonic organ development IMP
IMP: 通过突变表型推断
20589884 MGI
acts upstream of or within endoderm development IMP
IMP: 通过突变表型推断
20589884 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
20630950 MGI
acts upstream of or within neural tube closure IMP
IMP: 通过突变表型推断
20630950 MGI
acts upstream of or within neural tube development IMP
IMP: 通过突变表型推断
20589884 MGI
acts upstream of or within oligodendrocyte development IMP
IMP: 通过突变表型推断
23575864 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: 通过突变表型推断
20589884 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: 通过突变表型推断
20720539 MGI
acts upstream of or within somitogenesis IMP
IMP: 通过突变表型推断
20589884 MGI
acts upstream of or within spinal cord development IMP
IMP: 通过突变表型推断
20589884 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of mediator complex IDA
IDA: 通过直接分析推断
15340084 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

mediator of RNA polymerase II transcription subunit 12

OPA-containing protein 1

mediator of RNA polymerase II transcription, subunit 12 homolog

thyroid hormone receptor-associated protein complex 230 kDa component

trinucleotide repeat containing 11 (THR-associated protein)

trinucleotide repeat containing

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-114965 TP-064 Inhibitor 99.61% 否
HY-100360 MS049 Inhibitor 98.0% 否
HY-RS08281 MED12 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-100360A MS049 dihydrochloride Inhibitor / 否
HY-RS08282 MED12L Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18290 Med12 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24768 Med12 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Med12 NCBI NCBI:9968
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