KDM5A - lysine demethylase 5A Gene

中文名称：赖氨酸脱甲基酶 5A

种属: Homo sapiens

同用名: RBP2; RBBP2; RBBP-2

基因 ID: 5927 | 基因类型: protein coding

关于 KDM5A

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:280,057-389,320 (from NCBI)

This gene has 11 transcripts (splice variants), 211 orthologues, 10 paralogues and is associated with 97 phenotypes. Ubiquitous expression in testis (RPKM 10.6), bone marrow (RPKM 8.6) and 25 other tissues.

功能概要

该基因编码 Jumonji、富含 AT 的相互作用结构域 1 (JARID1) 组蛋白去甲基化酶蛋白家族的成员。编码的蛋白质通过特异性去甲基化组蛋白 H3 的赖氨酸 4，通过组蛋白密码在基因调控中发挥作用。编码的蛋白质与许多其他蛋白质相互作用，包括视网膜母细胞瘤蛋白，并且涉及 Hox 基因和细胞因子的转录调节。该基因可能在肿瘤进展中发挥作用。[RefSeq 提供，2013 年 8 月]

This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) Histone Demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many Other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]

KDM5A 基因产物(1)

mRNA	Protein	Name
NM_001042603.3	NP_001036068.1	lysine-specific demethylase 5A

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	15640446	GOA
enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity	IDA IDA: 通过直接分析推断	18270511	GOA
enables histone binding	IDA IDA: 通过直接分析推断	19430464	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21960634	GOA
enables transcription cis-regulatory region binding	IMP IMP: 通过突变表型推断	18270511	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	19430464	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11358960	GOA
involved in regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	18270511	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	18270511	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KDM5A 蛋白结构

JmjN

ARID

PHD

JmjC

zf-C5HC2

PLU-1

PHD

0
300
600
900
1200
1500
1690 a.a.

蛋白主名

其他名称

lysine-specific demethylase 5A

Jumonji, AT rich interactive domain 1A (RBP2-like)

KDM5A 抗体

目录号	产品名	应用	反应物种
HY-P81819	KDM5A Antibody (YA1564)	WB, ICC/IF, IP, FC	Human, Mouse

关联疾病

疾病名称

别名

Acute Megakaryoblastic Leukemia Without Down Syndrome

Non-Ds-Amkl

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Childhood Acute Myeloid Leukemia

Childhood Acute Myeloid Leukaemia	Paediatric Acute Myeloid Leukaemia
Pediatric Acute Myeloid Leukemia

Childhood Acute Megakaryoblastic Leukemia

Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia

Syndromic X-Linked Intellectual Disability Claes-Jensen Type

Mental Retardation, X-Linked, Syndromic, Claes-Jensen Type	Mrxscj
Mrxsj	Syndromic X-Linked Intellectual Disability Due To Jarid1c Mutation
Syndromic X-Linked Mental Retardation Jarid1c-Related

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Idiopathic Peripheral Autonomic Neuropathy

Acute Megakaryocytic Leukemia

Acute Megakaryoblastic Leukemia	Acute Megakaryoblastic Leukaemia
Megakaryocytic Myelosis	Thrombocytic Leukaemia
Amkl	Aml M7
Acute Myeloblastic Leukemia Type 7	Acute Myeloid Leukemia M7
Megakaryoblastic Leukemia Acute	Leukemia, Megakaryoblastic, Acute
Acute Myeloid Leukaemia, M7	Acute Megakaryocytic Leukaemia
Acute Megakaryoblastic Leukaemia, Fab M7	Fab M7
Malignant Megakaryocytosis	M7 - Acute Megakaryoblastic Leukaemia
Megakaryoblastic Leukaemia	Megakaryocytic Leukaemia
Acute Megakaryoblastic Leukaemia, Nos	Acute Megakaryoblastic Leukaemia Without Mention Of Remission

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-100421	CPI-455	Inhibitor	98.95%	否
HY-102047B	KDOAM-25 citrate	Inhibitor	98.56%	否
HY-100014	KDM5A-IN-1	Inhibitor	99.64%	否
HY-107573	KDM2/7-IN-1	Inhibitor	99.00%	否
HY-119397A	KDM5-C49 hydrochloride	Inhibitor	96.64%	否
HY-144501	D18		98.79%	否
HY-100624	Ryuvidine	Inhibitor	99.40%	否
HY-100764	YUKA1	Inhibitor	99.15%	否
HY-123419	CPI-4203	Inhibitor	≥99.0%	否
HY-100421A	CPI-455 hydrochloride	Inhibitor	99.95%	否
HY-102047	KDOAM-25	Inhibitor	/	否
HY-RS07218	KDM5A Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-102047A	KDOAM-25 trihydrochloride	Inhibitor	/	否
HY-119397	KDM5-C49	Inhibitor	/	否
HY-RS16664	Kdm5a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23099	Kdm5a Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	KDM5A	VGNC	VGNC:30530
Felis catus	KDM5A	VGNC	VGNC:69256
Canis familiaris	KDM5A	VGNC	VGNC:42327
Macaca mulatta	KDM5A	VGNC	VGNC:82169
Mus musculus	KDM5A	MGD	MGI:2136980
Rattus norvegicus	KDM5A	RGD	RGD:1305429
Others	KDM5A	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KDM5A - lysine demethylase 5A Gene

关于 KDM5A

功能概要

KDM5A 基因产物(1)

KDM5A 蛋白结构

KDM5A 抗体

关联疾病

直系同源

热门区域

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KDM5A - lysine demethylase 5A Gene

关于 KDM5A

功能概要

KDM5A 基因产物(1)

KDM5A 蛋白结构

KDM5A 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z